Protein: DLDH
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein)

Gene: DLDH, lpdA
Organism: Escherichia coli K-12
Interactions: 93
UniProt ID: P0A9P0

Gene Ontology (top 5):
GO:0004148 - dihydrolipoyl dehydrogenase (NADH) activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005960 - glycine cleavage complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449830

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

4

16

High-throughput

0.898

High

497013

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex

3

16

High-throughput

0.856

High

496993

DLDH
Dihydrolipoyl dehydrogenase

2

15

Small-scale

0.754

High

497017

THIO2
Thioredoxin 2

1

11

High-throughput

0.691

High

497033

NAPA
Periplasmic nitrate reductase

1

0

High-throughput

0.656

High

497014

ODP1
Pyruvate dehydrogenase E1 component

2

0

High-throughput

0.585

High

497025

TRHO
tRNA uridine(34) hydroxylase

1

0

High-throughput

0.578

High

365869

DPO1
DNA polymerase I

1

1

High-throughput

0.536

High

395147

UVRD
DNA helicase II

1

2

High-throughput

0.536

High

444286

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

469921

RECB
RecBCD enzyme subunit RecB

1

2

High-throughput

0.536

High

477370

T1RK
Type I restriction enzyme EcoKI endonuclease subunit

1

3

High-throughput

0.536

High

478367

EX3
Exodeoxyribonuclease III

1

1

High-throughput

0.536

High

489334

ISCS
Cysteine desulfurase IscS

1

2

High-throughput

0.536

High

495325

UVRB
UvrABC system protein B

1

1

High-throughput

0.536

High

497022

RECQ
ATP-dependent DNA helicase RecQ

1

1

High-throughput

0.536

High

497026

MNME
tRNA modification GTPase MnmE

1

1

High-throughput

0.536

High

497028

RAVA
Regulatory ATPase RavA

1

2

High-throughput

0.536

High

497032

YEJF
Uncharacterized ABC transporter ATP-binding protein YejF

1

1

High-throughput

0.536

High

497035

CSPB
Cold shock-like protein CspB

1

2

High-throughput

0.536

High

497051

FADI
3-ketoacyl-CoA thiolase FadI

1

2

High-throughput

0.536

High

497054

FADJ
Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase

1

1

High-throughput

0.536

High

361744

PHSM
Maltodextrin phosphorylase

1

0

High-throughput

0.513

High

395073

DNAA
Chromosomal replication initiator protein DnaA

1

0

High-throughput

0.513

High

466609

ILVB
Acetolactate synthase isozyme 1 large subunit

1

0

High-throughput

0.513

High

492346

RIBB
3,4-dihydroxy-2-butanone 4-phosphate synthase

1

0

High-throughput

0.513

High

495349

UVRC
UvrABC system protein C

1

0

High-throughput

0.513

High

496996

RLUC
Ribosomal large subunit pseudouridine synthase C

1

0

High-throughput

0.513

High

496997

YBAK
Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK

1

0

High-throughput

0.513

High

497003

CHEY
Chemotaxis protein CheY

1

0

High-throughput

0.513

High

497020

DPO3A
DNA polymerase III subunit alpha

1

0

High-throughput

0.513

High

497024

YICC
Endoribonuclease YicC

1

0

High-throughput

0.513

High

497030

FDHD
Sulfur carrier protein FdhD

1

0

High-throughput

0.513

High

497031

DUSC
tRNA-dihydrouridine(16) synthase

1

0

High-throughput

0.513

High

497034

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.513

High

497042

END8
Endonuclease 8

1

0

High-throughput

0.513

High

497045

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.513

High

497048

BLUF
Blue light- and temperature-regulated antirepressor BluF

1

0

High-throughput

0.513

High

497052

LYSAC
Peptidyl-lysine N-acetyltransferase PatZ

1

0

High-throughput

0.513

High

497053

DGCM
Diguanylate cyclase DgcM

1

0

High-throughput

0.513

High

497027

GLUQ
Glutamyl-Q tRNA(Asp) synthetase

1

2

High-throughput

0.500

High

497021

TOP3
DNA topoisomerase 3

1

1

High-throughput

0.489

High

497036

HRPB
ATP-dependent RNA helicase HrpB

1

1

High-throughput

0.489

High

497038

IDND
L-idonate 5-dehydrogenase

1

1

High-throughput

0.489

High

497055

YDJF
Uncharacterized HTH-type transcriptional regulator YdjF

1

1

High-throughput

0.489

High

489289

ACP
Acyl carrier protein

1

3

High-throughput

0.484

High

496994

ULAR
HTH-type transcriptional regulator UlaR

1

1

High-throughput

0.484

High

496995

ZNUC
Zinc import ATP-binding protein ZnuC

1

1

High-throughput

0.484

High

497007

GYRA
DNA gyrase subunit A

1

1

High-throughput

0.484

High

497012

ODO1
2-oxoglutarate dehydrogenase E1 component

1

9

High-throughput

0.484

High

497016

PARC
DNA topoisomerase 4 subunit A

1

1

High-throughput

0.484

High

497018

IBPA
Small heat shock protein IbpA

1

1

High-throughput

0.484

High

497019

IBPB
Small heat shock protein IbpB

1

1

High-throughput

0.484

High

489530

CH60
Chaperonin GroEL

1

1

Small-scale

0.479

High

489379

END4
Endonuclease 4

1

0

High-throughput

0.464

High

490773

RSMG
Ribosomal RNA small subunit methyltransferase G

1

0

High-throughput

0.464

High

492033

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.464

High

492093

PPK1
Polyphosphate kinase

1

0

High-throughput

0.464

High

494540

RNH
Ribonuclease HI

1

0

High-throughput

0.464

High

495120

UBIE
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

1

0

High-throughput

0.464

High

496626

LDCI
Inducible lysine decarboxylase

1

0

High-throughput

0.464

High

496714

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

496998

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.464

High

497004

UVRY
Response regulator UvrY

1

0

High-throughput

0.464

High

497006

FUCM
L-fucose mutarotase

1

0

High-throughput

0.464

High

497009

NARJ
Nitrate reductase molybdenum cofactor assembly chaperone NarJ

1

0

High-throughput

0.464

High

497010

RRAB
Regulator of ribonuclease activity B

1

0

High-throughput

0.464

High

497015

OGT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.464

High

497044

NFI
Endonuclease V

1

0

High-throughput

0.464

High

495430

TRMB
tRNA

1

2

High-throughput

0.442

High

497000

SURA
Chaperone SurA

1

2

High-throughput

0.442

High

420202

RECD
RecBCD enzyme subunit RecD

1

0

High-throughput

0.279

Low

497001

PDHR
Pyruvate dehydrogenase complex repressor

1

0

High-throughput

0.279

Low

497011

NUDB
Dihydroneopterin triphosphate diphosphatase

1

0

High-throughput

0.279

Low

497023

RECJ
Single-stranded-DNA-specific exonuclease RecJ

1

0

High-throughput

0.279

Low

497029

NNR
Bifunctional NAD(P)H-hydrate repair enzyme Nnr

1

0

High-throughput

0.279

Low

497037

INTS
Prophage integrase IntS

1

0

High-throughput

0.279

Low

497039

HRPA
ATP-dependent RNA helicase HrpA

1

0

High-throughput

0.279

Low

497040

YRAN
UPF0102 protein YraN

1

0

High-throughput

0.279

Low

497041

UBIU
Ubiquinone biosynthesis protein UbiU

1

0

High-throughput

0.279

Low

497043

YGFF
Uncharacterized oxidoreductase YgfF

1

0

High-throughput

0.279

Low

497046

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.279

Low

497047

BLUR
HTH-type transcriptional repressor BluR

1

0

High-throughput

0.279

Low

497049

PAAX
Transcriptional repressor PaaX

1

0

High-throughput

0.279

Low

497050

YNFB
UPF0482 protein YnfB

1

0

High-throughput

0.279

Low

497056

UACR
Putative uric acid sigma-54-dependent transcriptional regulator UacR

1

0

High-throughput

0.279

Low

432415

T1SK
Type I restriction enzyme EcoKI specificity subunit

1

0

High-throughput

0.261

Low

494556

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

496999

END3
Endonuclease III

1

0

High-throughput

0.253

Low

497002

PINR
Serine recombinase PinR

1

0

High-throughput

0.253

Low

497005

DMA
DNA adenine methylase

1

0

High-throughput

0.253

Low

497008

HYCI
Hydrogenase 3 maturation protease

1

0

High-throughput

0.253

Low


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Last updated: 11Aug2025