HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048167 - regulation of synaptic plasticity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1692
+	Hs
		654006 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		1200041 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		497164 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT6_HUMAN (435-887): 1.53e-54: 201: 15.34
+	Hs
		497461 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NED4L_HUMAN (1535-1687): 4.67e-28: 125: 21.12
+	Rn
		581944 TAU_RAT (1-758): 4.86e-75: 260: 71.47		RP3A_RAT (502-971): 9.79e-35: 145: 13.83
+	Rn
		94168 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		RP3A_RAT (502-971): 9.79e-35: 145: 13.83
+	Hs
		207687 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT7_HUMAN (1326-1660): 1.49e-21: 101: 13.37
+	Hs
		496296 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT1_HUMAN (744-872): 2.38e-18: 91.5: 21.13
+	Hs
		129078 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT5_HUMAN (634-842): 9.58e-18: 89.2: 23.81
+	Hs
		497309 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT2_HUMAN (733-889): 2e-17: 88.8: 23.57
+	Hs
		496245 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCA_HUMAN (1540-1659): 1.74e-12: 74.6: 31.15
+	Rn
		581931 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYT2_RAT (733-889): 1.96e-17: 88.8: 23.57
+	Rn
		94153 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYT2_RAT (733-889): 1.96e-17: 88.8: 23.57
+	Mm
		498119 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SYTL2_MOUSE (899-1657): 5.36e-15: 83: 13.96
+	Hs
		503299 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		NED4L_HUMAN (1535-1687): 4.67e-28: 125: 21.12
+	Mm
		1351630 PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66		PCLO_MOUSE (1446-1663): 1.87e-29: 131: 21.65
+	Mm
		1322317 PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66		RIMS2_MOUSE (275-869): 1.22e-16: 88.5: 15.36
+	Dm
		1212944 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q8IM87_DROME (1495-1669): 3.44e-11: 70.8: 19.05