HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DCLK2 (Q8N568)
Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
Gene: DCLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0008017 - microtubule binding GO:0015630 - microtubule cytoskeleton
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 766
+	Mm
		498062 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DCLK2_MOUSE (1-766): 0: 767: 92.69
+	Hs
		166531 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DCLK1_HUMAN (1-744): 0: 675: 65.34
+	Mm
		498146 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DCLK1_MOUSE (1-744): 0: 671: 62.57
+	Hs
		277594 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PAK3_HUMAN (147-652): 1.5e-141: 429: 20.73
+	Hs
		208239 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DCX_HUMAN (6-354): 9.62e-138: 412: 66.94
+	Hs
		496976 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2B_HUMAN (388-757): 1.89e-131: 407: 33.50
+	Hs
		496977 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2D_HUMAN (388-698): 3.75e-133: 405: 37.46
+	Hs
		497824 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2A_HUMAN (388-712): 8.55e-133: 403: 37.08
+	Hs
		92372 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E9PBG7_HUMAN (388-748): 4.71e-132: 403: 33.43
+	Rn
		439487 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2B_RAT (388-760): 2.46e-136: 415: 33.76
+	Rn
		94121 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2B_RAT (388-760): 2.46e-136: 415: 33.76
+	Rn
		506692 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2A_RAT (388-699): 1.12e-132: 403: 37.98
+	Rn
		94129 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2A_RAT (388-699): 1.12e-132: 403: 37.98
+	Rn
		514946 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2G_RAT (388-697): 1.56e-130: 400: 38.22
+	Rn
		94132 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2G_RAT (388-697): 1.56e-130: 400: 38.22
+	Mm
		498111 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KCC2G_MOUSE (388-759): 1.42e-131: 402: 33.68
+	Hs
		208243 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		DCX_HUMAN (6-354): 9.62e-138: 412: 66.94
+	Mm
		592770 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		KCC2D_MOUSE (388-698): 3.75e-133: 405: 37.46
+	Rn
		506773 PCLO_RAT (3-721): 3.96e-10: 65.9: 8.48		KCC2A_RAT (388-699): 1.12e-132: 403: 37.98