HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: E41L1 (Q9H4G0)
Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)
Gene: EPB41L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 881
+	Hs
		2032 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		A0A0A0MRA8_HUMAN (1-875): 0: 592: 46.77
+	Hs
		204602 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E41L2_HUMAN (3-875): 0: 561: 42.93
+	Hs
		497875 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TLN2_HUMAN (42-879): 8.87e-131: 435: 12.29
+	Hs
		497874 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FARP1_HUMAN (75-603): 7.66e-132: 422: 31.37
+	Hs
		497870 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TLN1_HUMAN (42-879): 3.41e-119: 401: 10.75
+	Hs
		496432 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		496224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		496433 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44
+	Dm
		1370280 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VSL8_DROME (45-877): 8.65e-137: 453: 14.22
+	Hs
		640255 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		PTN3_HUMAN (69-717): 3e-138: 436: 24.14
+	Hs
		297842 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		E41LA_HUMAN (94-761): 3.88e-129: 405: 24.60
+	Hs
		497839 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E41L3_HUMAN (458-875): 1.5e-50: 195: 29.79
+	Hs
		297816 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44
+	Dm
		1215527 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q8IRJ0_DROME (192-567): 1.77e-126: 403: 34.57
+	Dm
		1370353 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9W0R3_DROME (59-567): 1.33e-123: 399: 32.69
+	Hs
		203207 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		496167 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EPB41_HUMAN (528-872): 1.64e-35: 147: 21.88