HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PLCB1 (Q9NQ66)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)
Gene: PLCB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007613 - memory GO:0016607 - nuclear speck and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1216
+	Hs
		497050 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCB4_HUMAN (16-1155): 0: 1002: 38.85
+	Hs
		496595 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Dm
		632600 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		PIP1_DROME (17-1153): 0: 934: 37.66
+	Hs
		496268 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG1_HUMAN (491-792): 9.61e-80: 289: 31.29
+	Hs
		496239 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG2_HUMAN (487-867): 1.38e-72: 267: 24.87
+	Hs
		580935 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PLCG1_HUMAN (491-792): 9.61e-80: 289: 31.29