Protein: RLUB
Ribosomal large subunit pseudouridine synthase B (EC 5.4.99.22) (23S rRNA pseudouridine(2605) synthase) (rRNA pseudouridylate synthase B) (rRNA-uridine isomerase B)

Gene: RLUB
Organism: Escherichia coli K-12
Interactions: 98
UniProt ID: P37765

Gene Ontology (top 5):
GO:0000455 - enzyme-directed rRNA pseudouridine synthesis
GO:0003723 - RNA binding
GO:0005829 - cytosol
GO:0120159 - rRNA pseudouridine synthase activity
GO:0160139 - 23S rRNA pseudouridine(2605) synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

790858

RLUE
Ribosomal large subunit pseudouridine synthase E

2

2

High-throughput

0.789

High

497641

RLUC
Ribosomal large subunit pseudouridine synthase C

1

3

High-throughput

0.724

High

638610

SRMB
ATP-dependent RNA helicase SrmB

2

4

High-throughput

0.640

High

790856

RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase

2

3

High-throughput

0.640

High

382736

RS7
Small ribosomal subunit protein uS7

2

4

High-throughput

0.633

High

494165

RS4
Small ribosomal subunit protein uS4

1

3

High-throughput

0.625

High

790848

RL4
Large ribosomal subunit protein uL4

2

3

High-throughput

0.612

High

368831

SYA
Alanine--tRNA ligase

2

1

High-throughput

0.611

High

638579

RNR
Ribonuclease R

2

2

High-throughput

0.611

High

663206

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

2

1

High-throughput

0.611

High

790844

HRPA
ATP-dependent RNA helicase HrpA

2

1

High-throughput

0.611

High

496298

CSPE
Cold shock-like protein CspE

2

10

High-throughput

0.601

High

491669

KPRS
Ribose-phosphate pyrophosphokinase

2

1

High-throughput

0.594

High

492637

RL19
Large ribosomal subunit protein bL19

2

2

High-throughput

0.588

High

492978

RL28
Large ribosomal subunit protein bL28

2

1

High-throughput

0.588

High

493424

RS13
Small ribosomal subunit protein uS13

2

2

High-throughput

0.588

High

493548

RS18
Small ribosomal subunit protein bS18

2

5

High-throughput

0.588

High

493648

RS20
Small ribosomal subunit protein bS20

2

1

High-throughput

0.588

High

493960

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.588

High

497385

CSPA
Cold shock protein CspA

2

10

High-throughput

0.588

High

497430

CSPC
Cold shock-like protein CspC

2

10

High-throughput

0.588

High

499739

YIBL
Uncharacterized protein YibL

2

2

High-throughput

0.588

High

501248

RL21
Large ribosomal subunit protein bL21

2

1

High-throughput

0.588

High

501292

RL6
Large ribosomal subunit protein uL6

2

1

High-throughput

0.588

High

501395

RS1
Small ribosomal subunit protein bS1

2

3

High-throughput

0.588

High

790847

RL24
Large ribosomal subunit protein uL24

2

2

High-throughput

0.588

High

444317

TOP1
DNA topoisomerase 1

2

0

High-throughput

0.585

High

790763

RDSA
Ribosomal RNA dihydrouridine synthase

2

0

High-throughput

0.585

High

790851

YHBP
UPF0306 protein YhbP

2

0

High-throughput

0.563

High

790852

RS21
Small ribosomal subunit protein bS21

2

0

High-throughput

0.563

High

790853

RL25
Large ribosomal subunit protein bL25

2

0

High-throughput

0.563

High

382593

RS6
Small ribosomal subunit protein bS6

1

1

High-throughput

0.561

High

421126

PNP
Polyribonucleotide nucleotidyltransferase

1

3

High-throughput

0.561

High

639464

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

1

2

High-throughput

0.561

High

790766

RLMJ
Ribosomal RNA large subunit methyltransferase J

1

1

High-throughput

0.561

High

750366

AIDB
Putative acyl-CoA dehydrogenase AidB

2

2

High-throughput

0.558

High

494576

RNPA
Ribonuclease P protein component

2

1

High-throughput

0.549

High

491948

RPPH
RNA pyrophosphohydrolase

2

1

High-throughput

0.537

High

501339

RS14
Small ribosomal subunit protein uS14

2

3

High-throughput

0.537

High

638628

RNE
Ribonuclease E

1

0

High-throughput

0.537

High

788371

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.537

High

494323

RS5
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

500811

ODP1
Pyruvate dehydrogenase E1 component

1

1

High-throughput

0.536

High

604582

BETB
Betaine aldehyde dehydrogenase

1

1

High-throughput

0.536

High

790846

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.536

High

492140

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.513

High

722844

3PASE
Inorganic triphosphatase

1

1

High-throughput

0.512

High

790857

RLMI
Ribosomal RNA large subunit methyltransferase I

1

3

High-throughput

0.500

High

493808

RS2
Small ribosomal subunit protein uS2

1

4

High-throughput

0.489

High

492780

RL1
Large ribosomal subunit protein uL1

1

3

High-throughput

0.484

High

493179

RL9
Large ribosomal subunit protein bL9

1

5

High-throughput

0.484

High

493270

RS10
Small ribosomal subunit protein uS10

1

4

High-throughput

0.484

High

496266

CSPD
Cold shock-like protein CspD

1

10

High-throughput

0.484

High

497113

DEAD
ATP-dependent RNA helicase DeaD

1

2

High-throughput

0.484

High

497523

RL13
Large ribosomal subunit protein uL13

1

3

High-throughput

0.484

High

497999

YBCJ
Putative RNA-binding protein YbcJ

1

1

High-throughput

0.484

High

499082

DBHA
DNA-binding protein HU-alpha

1

4

High-throughput

0.484

High

501104

SPOT
Bifunctional

1

1

High-throughput

0.484

High

501612

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

3

High-throughput

0.484

High

501649

YHBY
RNA-binding protein YhbY

1

1

High-throughput

0.484

High

790845

RL2
Large ribosomal subunit protein uL2

1

5

High-throughput

0.484

High

790849

RL22
Large ribosomal subunit protein uL22

1

2

High-throughput

0.484

High

790850

RL5
Large ribosomal subunit protein uL5

1

1

High-throughput

0.484

High

490938

IHFA
Integration host factor subunit alpha

1

4

High-throughput

0.479

High

492845

RL20
Large ribosomal subunit protein bL20

1

3

High-throughput

0.479

High

495586

TMAR
Pole-localizer protein TmaR

1

1

High-throughput

0.479

High

499122

DBHB
DNA-binding protein HU-beta

1

4

High-throughput

0.479

High

501194

RL17
Large ribosomal subunit protein bL17

1

3

High-throughput

0.479

High

501678

RL18
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

490904

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

494895

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

496733

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

361753

PHSM
Maltodextrin phosphorylase

1

0

High-throughput

0.458

High

490422

DAPF
Diaminopimelate epimerase

1

0

High-throughput

0.458

High

491509

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.458

High

493581

RS19
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

495407

YIHI
Der GTPase-activating protein YihI

1

0

High-throughput

0.458

High

498311

PCNB
Poly(A) polymerase I

1

0

High-throughput

0.458

High

499604

KPYK1
Pyruvate kinase I

1

0

High-throughput

0.458

High

500644

RRAB
Regulator of ribonuclease activity B

1

0

High-throughput

0.458

High

790854

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

786969

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

1

High-throughput

0.457

High

493510

RS16
Small ribosomal subunit protein bS16

1

4

High-throughput

0.442

High

497247

YBHF
Probable multidrug ABC transporter ATP-binding protein YbhF

1

1

High-throughput

0.442

High

384049

RL15
Large ribosomal subunit protein uL15

1

2

High-throughput

0.437

High

499903

RL16
Large ribosomal subunit protein uL16

1

1

High-throughput

0.437

High

790859

YNCE
Uncharacterized protein YncE

1

1

High-throughput

0.437

High

569571

SELB
Selenocysteine-specific elongation factor

2

0

High-throughput

0.318

High

704765

YHCA
Uncharacterized fimbrial chaperone YhcA

1

0

High-throughput

0.279

Low

726727

CBRC
UPF0167 protein CbrC

1

0

High-throughput

0.279

Low

728729

YCIK
Uncharacterized oxidoreductase YciK

1

0

High-throughput

0.279

Low

732773

MOBA
Molybdenum cofactor guanylyltransferase

1

0

High-throughput

0.279

Low

790855

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.279

Low

790860

ECPB
Probable fimbrial chaperone EcpB

1

0

High-throughput

0.279

Low

790861

RNM
5'-3' exoribonuclease Rnm

1

0

High-throughput

0.279

Low

492045

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.253

Low

494713

RUVA
Holliday junction branch migration complex subunit RuvA

1

0

High-throughput

0.249

Low

790862

YGIQ
UPF0313 protein YgiQ

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025