HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DDX21 (Q9NR30)
Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)
Gene: DDX21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0003723 - RNA binding GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 783
+	Hs
		497260 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX42_HUMAN (2-757): 4.87e-137: 430: 20.41
+	Hs
		497386 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX17_HUMAN (122-628): 1.38e-136: 423: 24.46
+	Hs
		133854 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX3X_HUMAN (5-575): 3.96e-137: 422: 23.55
+	Hs
		496251 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX5_HUMAN (92-620): 4.08e-135: 415: 24.81
+	Mm
		498030 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX17_MOUSE (122-628): 3.34e-135: 417: 24.46
+	Mm
		498084 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BTS0_MOUSE (92-620): 1.47e-135: 416: 24.81
+	Mm
		498056 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX3Y_MOUSE (5-600): 6.18e-131: 406: 23.57
+	Hs
		757612 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		IF4A3_HUMAN (169-554): 5.06e-54: 194: 32.23