HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0033044 - regulation of chromosome organization
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 456
+	Hs
		497826 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1170099 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Dm
		1366586 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		RUVB1_DROME (1-455): 0: 660: 79.56
+	Hs
		1170098 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		RUVB2_HUMAN (2-455): 0: 651: 42.76