Protein: CYPH
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (CPH) (Cyclosporin A-binding protein) (PPI-II) (Rotamase)

Gene: CYPH, CPR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 192
UniProt ID: P14832

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575880

CYPH
Peptidyl-prolyl cis-trans isomerase

3

10

High-throughput

0.817

High

575932

SIF2
SIR4-interacting protein SIF2

7

3

Small-scale

0.744

High

575897

SNT1
Probable DNA-binding protein SNT1

6

3

Small-scale

0.729

High

575896

SIS1
Protein SIS1

2

0

High-throughput

0.716

High

575955

HOS4
Protein HOS4

5

4

Small-scale

0.712

High

575975

HOS2
Probable histone deacetylase HOS2

5

4

Small-scale

0.709

High

575925

SET3
SET domain-containing protein 3

5

6

Small-scale

0.699

High

575959

IST3
U2 snRNP component IST3

1

6

High-throughput

0.691

High

576030

HSH49
Protein HSH49

1

3

High-throughput

0.691

High

576026

RUVB2
RuvB-like protein 2

4

1

High-throughput

0.678

High

576024

SMT3
Ubiquitin-like protein SMT3

3

7

Small-scale

0.650

High

517870

SSBP1
Single-stranded nucleic acid-binding protein

1

7

High-throughput

0.647

High

392142

HSP82
ATP-dependent molecular chaperone HSP82

3

11

High-throughput

0.640

High

381841

H4
Histone H4

3

1

High-throughput

0.634

High

449050

CALM
Calmodulin

2

4

High-throughput

0.621

High

575889

SNF2
Transcription regulatory protein SNF2

2

3

High-throughput

0.621

High

575983

RHO5
GTP-binding protein RHO5

1

9

Small-scale

0.621

High

575946

TEM1
Protein TEM1

1

3

High-throughput

0.618

High

576022

PUF2
mRNA-binding protein PUF2

1

1

High-throughput

0.618

High

575964

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

575883

HSC82
ATP-dependent molecular chaperone HSC82

2

11

High-throughput

0.571

High

575943

KOG1
Target of rapamycin complex 1 subunit KOG1

2

3

High-throughput

0.571

High

576004

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.571

High

525815

HSP72
Heat shock protein SSA2

2

12

High-throughput

0.552

High

575951

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

575997

SDC1
COMPASS component SDC1

1

0

High-throughput

0.546

High

575895

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

1

High-throughput

0.536

High

575947

DUN1
DNA damage response protein kinase DUN1

1

2

High-throughput

0.536

High

575990

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

575963

BUD27
Bud site selection protein 27

1

0

Small-scale

0.518

High

575904

CGS5
S-phase entry cyclin-5

1

4

High-throughput

0.515

High

575911

RPD3
Histone deacetylase RPD3

1

6

Small-scale

0.515

High

575952

CCS1
Superoxide dismutase 1 copper chaperone

1

4

High-throughput

0.515

High

449274

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.513

High

575881

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.513

High

575891

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.513

High

575893

MPIP
M-phase inducer phosphatase

1

0

High-throughput

0.513

High

575900

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.513

High

575985

IGO1
mRNA stability protein IGO1

1

0

High-throughput

0.513

High

576014

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

380943

H2B1
Histone H2B.1

1

1

Small-scale

0.501

High

575909

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

0

High-throughput

0.493

High

575936

SAP30
Transcriptional regulatory protein SAP30

1

0

Small-scale

0.493

High

575981

HST1
NAD-dependent protein deacetylase HST1

1

0

Small-scale

0.493

High

576011

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.493

High

576019

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.493

High

576020

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.493

High

575966

BBC1
Myosin tail region-interacting protein MTI1

1

6

High-throughput

0.489

High

575957

ULP2
Ubiquitin-like-specific protease 2

1

4

High-throughput

0.481

High

575958

MPH1
ATP-dependent DNA helicase MPH1

1

12

Small-scale

0.481

High

575993

ULP1
Ubiquitin-like-specific protease 1

1

4

High-throughput

0.481

High

358954

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

359420

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.479

High

364299

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.479

High

364899

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.479

High

365543

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

367671

ENO1
Enolase 1

1

3

High-throughput

0.479

High

367875

ENO2
Enolase 2

1

3

High-throughput

0.479

High

368573

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.479

High

401856

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.479

High

408388

GAL4
Regulatory protein GAL4

1

1

Small-scale

0.479

High

504565

YD14B
Transposon Ty1-DR5 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

504611

YL13B
Transposon Ty1-LR3 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

575887

SFL1
Flocculation suppression protein

1

1

High-throughput

0.479

High

575892

TKT1
Transketolase 1

1

1

High-throughput

0.479

High

575898

YC21B
Transposon Ty2-C Gag-Pol polyprotein

1

8

High-throughput

0.479

High

575899

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

575902

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

575903

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.479

High

575906

SWC3
SWR1-complex protein 3

1

1

High-throughput

0.479

High

575917

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.479

High

575918

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

575919

IXR1
Intrastrand cross-link recognition protein

1

8

Small-scale

0.479

High

575928

GBLP
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.479

High

575931

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.479

High

575934

SWC5
SWR1-complex protein 5

1

1

High-throughput

0.479

High

575939

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.479

High

575940

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

6

Small-scale

0.479

High

575944

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

575945

CH10
10 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

575967

YJ11B
Transposon Ty1-JR1 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

575968

YJ12B
Transposon Ty1-JR2 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

575987

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

575991

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

575992

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

575996

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

576000

YM12B
Transposon Ty1-ML2 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

576001

YE11B
Transposon Ty1-ER1 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

576003

GIS1
Transcriptional activator/repressor GIS1

1

3

High-throughput

0.479

High

576007

SWR1
Helicase SWR1

1

5

High-throughput

0.479

High

576013

PUF3
mRNA-binding protein PUF3

1

1

High-throughput

0.479

High

576021

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

576023

YB21A
Transposon Ty2-B Gag polyprotein

1

8

High-throughput

0.479

High

576027

YB11B
Transposon Ty1-BL Gag-Pol polyprotein

1

7

High-throughput

0.479

High

576028

ARP6
Actin-like protein ARP6

1

4

High-throughput

0.479

High

575971

CENPK
Inner kinetochore subunit MCM22

1

0

High-throughput

0.460

High

360935

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

368398

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

416358

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

439219

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

441669

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

450697

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

514420

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

554992

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

564636

STE12
Protein STE12

1

0

High-throughput

0.458

High

572498

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

575882

TAL1
Transaldolase

1

0

High-throughput

0.458

High

575885

TEC1
Ty transcription activator TEC1

1

0

High-throughput

0.458

High

575888

MSB1
Morphogenesis-related protein MSB1

1

0

High-throughput

0.458

High

575890

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

575905

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

575922

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

575938

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

575948

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

575956

VHR1
Transcription factor VHR1

1

0

High-throughput

0.458

High

575970

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

575973

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.458

High

575974

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

575978

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

575980

DCP2
m7GpppN-mRNA hydrolase

1

0

Small-scale

0.458

High

575995

COFI
Cofilin

1

0

High-throughput

0.458

High

575998

VPS72
Vacuolar protein sorting-associated protein 72

1

0

High-throughput

0.458

High

575999

VPS71
Vacuolar protein sorting-associated protein 71

1

0

High-throughput

0.458

High

576005

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

576008

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.458

High

576010

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

576016

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

361468

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.445

High

394180

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

445310

CDC31
Cell division control protein 31

1

5

High-throughput

0.445

High

477501

MYO1
Myosin-1

1

2

High-throughput

0.445

High

522926

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

543678

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

560641

KIN2
Serine/threonine-protein kinase KIN2

1

2

High-throughput

0.445

High

575886

MYO2
Myosin-2

1

3

High-throughput

0.445

High

575894

SSD1
Protein SSD1

1

1

High-throughput

0.445

High

575908

SP110
Spindle pole body component 110

1

6

High-throughput

0.445

High

575910

MYO4
Myosin-4

1

3

High-throughput

0.445

High

575912

TOR2
Serine/threonine-protein kinase TOR2

1

3

High-throughput

0.445

High

575921

TOR1
Serine/threonine-protein kinase TOR1

1

3

High-throughput

0.445

High

575929

AKL1
Serine/threonine-protein kinase AKL1

1

1

High-throughput

0.445

High

575937

KSP1
Serine/threonine-protein kinase KSP1

1

4

High-throughput

0.445

High

575942

SPC97
Spindle pole body component SPC97

1

1

High-throughput

0.445

High

575949

RSP5
E3 ubiquitin-protein ligase RSP5

1

7

High-throughput

0.445

High

575950

BEM2
GTPase-activating protein BEM2/IPL2

1

5

High-throughput

0.445

High

575979

SPC98
Spindle pole body component SPC98

1

1

High-throughput

0.445

High

575982

CNM67
Chaotic nuclear migration protein 67

1

3

High-throughput

0.445

High

575984

CBK1
Serine/threonine-protein kinase CBK1

1

2

High-throughput

0.445

High

575988

ACT
Actin

1

3

High-throughput

0.445

High

575989

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.445

High

576012

BRE1
E3 ubiquitin-protein ligase BRE1

1

7

High-throughput

0.445

High

576029

H2AZ
Histone H2A.Z

1

1

High-throughput

0.445

High

575915

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

575920

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

575927

VRP1
Verprolin

1

5

High-throughput

0.437

High

576018

AP3D
AP-3 complex subunit delta

1

4

High-throughput

0.437

High

553574

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.426

High

575884

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.426

High

575901

BUB2
Mitotic check point protein BUB2

1

0

High-throughput

0.426

High

575923

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.426

High

575924

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.426

High

575941

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.426

High

575953

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.426

High

575954

TAO3
Cell morphogenesis protein PAG1

1

0

High-throughput

0.426

High

575962

MOB2
CBK1 kinase activator protein MOB2

1

0

High-throughput

0.426

High

575969

BFA1
Mitotic check point protein BFA1

1

0

High-throughput

0.426

High

575972

ASK10
Activator of SKN7 protein 10

1

0

High-throughput

0.426

High

575994

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.426

High

576002

EFR3
Protein EFR3

1

0

High-throughput

0.426

High

576015

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.426

High

576025

BBP1
Spindle pole component BBP1

1

0

High-throughput

0.426

High

575960

LST8
Target of rapamycin complex subunit LST8

1

3

High-throughput

0.407

High

575961

COPB
Coatomer subunit beta

1

2

High-throughput

0.407

High

575976

MLC1
Myosin light chain 1

1

4

High-throughput

0.407

High

575913

CDC13
Cell division control protein 13

1

0

High-throughput

0.279

Low

575916

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.279

Low

575986

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.279

Low

576006

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

576009

ECM38
Glutathione hydrolase proenzyme

1

0

High-throughput

0.269

Low

383484

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

454836

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502811

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

575914

SKG6
Protein SKG6

1

0

High-throughput

0.249

Low

575933

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

575935

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

575926

VBA5
Vacuolar basic amino acid transporter 5

1

0

High-throughput

0.238

Low

575907

NUD1
Protein NUD1

1

0

High-throughput

0.232

Low

575930

NU170
Nucleoporin NUP170

1

0

High-throughput

0.232

Low

575965

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low

575977

MPS2
Monopolar spindle protein 2

1

0

High-throughput

0.232

Low

576017

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025