HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: DYR1B (Q9Y463)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)
Gene: DYRK1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 381 Hs			1 629
+	Hs
		498274 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		679232 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		498321 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		DYRK2_HUMAN (9-492): 1.61e-117: 364: 34.09
+	Hs
		498221 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		AKT1_HUMAN (6-429): 7.87e-119: 363: 18.41
+	Hs
		498215 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		533829 KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		414708 KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53		CDK1_HUMAN (108-434): 4.87e-121: 362: 27.76
+	Zm
		40342 A0A1D6QNV1_MAIZE (29-379): 1.02e-58: 207: 22.25		A0A1D6N7L2_MAIZE (117-433): 1.17e-49: 180: 34.20