HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 509
+	Hs
		499274 KIT_HUMAN (1-976): 0: 807: 100.00		SHC4_HUMAN (7-506): 3.96e-80: 263: 16.09
+	Hs
		499279 KIT_HUMAN (1-976): 0: 807: 100.00		SHC3_HUMAN (16-507): 3.95e-75: 249: 16.82
+	Hs
		499237 KIT_HUMAN (1-976): 0: 807: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		499256 KIT_HUMAN (1-976): 0: 807: 100.00		SHC2_HUMAN (106-507): 6.45e-63: 217: 15.07
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		499272 KIT_HUMAN (1-976): 0: 807: 100.00		TENS2_HUMAN (43-506): 4.48e-57: 207: 15.20
+	Hs
		256847 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS5_HUMAN (26-489): 3.54e-55: 195: 15.21
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (280-509): 1.78e-54: 193: 16.80
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337322 KIT_HUMAN (1-976): 0: 807: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		275165 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (354-490): 1.31e-17: 83.5: 20.86
+	Hs
		145969 PGFRB_HUMAN (30-954): 0: 591: 30.62		SH2B2_HUMAN (56-507): 1.2e-64: 223: 13.94
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16