HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0048863 - stem cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 630
+	Hs
		499237 KIT_HUMAN (1-976): 0: 807: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		499279 KIT_HUMAN (1-976): 0: 807: 100.00		SHC3_HUMAN (24-621): 5.09e-140: 422: 42.88
+	Hs
		499256 KIT_HUMAN (1-976): 0: 807: 100.00		SHC2_HUMAN (81-620): 1.11e-123: 379: 38.57
+	Hs
		499273 KIT_HUMAN (1-976): 0: 807: 100.00		TENS3_HUMAN (21-611): 4.44e-92: 312: 12.20
+	Hs
		499275 KIT_HUMAN (1-976): 0: 807: 100.00		SH2D3_HUMAN (331-619): 2.9e-45: 174: 17.16
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		499269 KIT_HUMAN (1-976): 0: 807: 100.00		SHB_HUMAN (356-617): 5.99e-44: 166: 20.73
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (367-628): 2.22e-43: 165: 16.12
+	Hs
		426940 KIT_HUMAN (1-976): 0: 807: 100.00		FES_HUMAN (384-629): 4.9e-42: 164: 20.16
+	Hs
		275529 KIT_HUMAN (1-976): 0: 807: 100.00		BCAR3_HUMAN (375-619): 1.73e-41: 163: 19.25
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (269-630): 5.78e-40: 159: 13.88
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Mm
		403530 KIT_MOUSE (1-975): 0: 773: 79.63		FES_MOUSE (384-629): 8.42e-41: 160: 18.95
+	Hs
		499235 KIT_HUMAN (1-976): 0: 807: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Mm
		403533 KIT_MOUSE (1-975): 0: 773: 79.63		P85A_MOUSE (506-622): 3.58e-20: 97.1: 24.19
+	Mm
		140055 KIT_MOUSE (1-975): 0: 773: 79.63		P85B_MOUSE (511-618): 1.17e-13: 76.1: 27.83
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (520-614): 1.23e-13: 72.2: 30.30
+	Mm
		404009 PGFRB_MOUSE (14-974): 0: 597: 29.51		P85A_MOUSE (506-622): 3.58e-20: 97.1: 24.19