HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0030183 - B cell differentiation GO:0035556 - intracellular signal transduction GO:0042169 - SH2 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 456
+	Hs
		129178 KIT_HUMAN (1-976): 0: 807: 100.00		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		499235 KIT_HUMAN (1-976): 0: 807: 100.00		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		140055 KIT_MOUSE (1-975): 0: 773: 79.63		P85B_MOUSE (131-453): 3.36e-43: 163: 16.27
+	Mm
		403533 KIT_MOUSE (1-975): 0: 773: 79.63		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		499280 KIT_HUMAN (1-976): 0: 807: 100.00		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		499273 KIT_HUMAN (1-976): 0: 807: 100.00		TENS3_HUMAN (10-436): 9.07e-25: 109: 15.25
+	Hs
		499272 KIT_HUMAN (1-976): 0: 807: 100.00		TENS2_HUMAN (45-436): 3.69e-23: 105: 18.06
+	Hs
		499288 KIT_HUMAN (1-976): 0: 807: 100.00		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Mm
		404009 PGFRB_MOUSE (14-974): 0: 597: 29.51		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		129176 PGFRB_HUMAN (30-954): 0: 591: 30.62		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		452361 PGFRB_HUMAN (30-954): 0: 591: 30.62		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		655242 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		738272 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Hs
		129199 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		601463 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		609182 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		1031146 PTK7_HUMAN (120-550): 1.42e-37: 154: 14.83		CLNK_HUMAN (73-443): 8.86e-38: 144: 21.35
+	Hs
		129201 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		607886 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		608065 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41