HitPredict

Interactor 1: ACRA (P0AE06)
Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A)
Gene: ACRA

Interactor 2: ACRA (P0AE06)
Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A)
Gene: ACRA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 24561554, 16079137, 16531241, 19805313, 19254725
Identification Methods two hybrid, blue native page, x-ray crystallography, surface plasmon resonance, cross-linking study, molecular sieving, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CusB_dom_1~CusB_dom_1, CusB_dom_1~HlyD_D23, HlyD_D23~HlyD_D23
Common GO terms GO:0005886 - plasma membrane
GO:0009410 - response to xenobiotic stimulus
GO:0009636 - response to toxic substance
GO:0015125 - bile acid transmembrane transporter activity
GO:0015567 - alkane transmembrane transporter activity
and 9 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 397
Ec

1 397
+ Ec
+ Ec
+ Bs
+ Ec

Service provided by Combinatics, Japan

Last updated: 11Aug2025