HitPredict

Interactor 1: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

Property	Details
Experiments	12907755, 19167335
Identification Methods	pull down, array technology, phosphatase assay
Interaction Type	direct interaction, dephosphorylation reaction

Property	Details
Interacting Pfam domains	EpoR_lig-bind~fn3, fn3~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 1997
+	Hs
		581148 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRB_HUMAN (1-1997): 0: 1320: 100.00
+	Hs
		500973 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRH_HUMAN (1-619): 2.64e-62: 236: 16.59
+	Hs
		441167 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		500961 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75
+	Hs
		500966 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10
+	Hs
		616945 IL2RG_HUMAN (27-352): 1.72e-44: 164: 13.99		PTPRD_HUMAN (902-1709): 1.7e-69: 262: 12.33
+	Hs
		489962 I13R2_HUMAN (23-282): 5.29e-43: 160: 16.67		PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82
+	Hs
		616942 IL3RA_HUMAN (41-316): 3.09e-40: 153: 13.73		PTPRD_HUMAN (902-1709): 1.7e-69: 262: 12.33
+	Hs
		1056195 I13R2_HUMAN (23-282): 5.29e-43: 160: 16.67		SDK2_HUMAN (3-473): 6e-50: 198: 14.84
+	Hs
		441174 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		581167 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46
+	Hs
		581149 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60
+	Hs
		581162 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75
+	Hs
		265768 CRLF1_HUMAN (8-257): 1.99e-55: 195: 19.62		PTPRS_HUMAN (2-201): 6.84e-11: 70: 12.73
+	Hs
		441190 LEPR_HUMAN (53-315): 1.77e-30: 130: 17.87		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		1031984 I13R2_HUMAN (23-282): 5.29e-43: 160: 16.67		PTPRS_HUMAN (2-201): 6.84e-11: 70: 12.73
+	Hs
		817318 LEPR_HUMAN (53-315): 1.77e-30: 130: 17.87		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75