Protein: EFTU1
Elongation factor Tu 1 (EF-Tu 1) (EC 3.6.5.3) (Bacteriophage Q beta RNA-directed RNA polymerase subunit III) (P-43)

Gene: EFTU1, tufA
Organism: Escherichia coli K-12
Interactions: 173
UniProt ID: P0CE47

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0003746 - translation elongation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

490552

EFTS
Elongation factor Ts

4

8

Small-scale

0.901

High

444347

ERA
GTPase Era

2

7

High-throughput

0.789

High

506248

EFTU2
Elongation factor Tu 2

2

9

High-throughput

0.767

High

490512

EFG
Elongation factor G

1

10

High-throughput

0.625

High

365877

DPO1
DNA polymerase I

2

2

High-throughput

0.611

High

368804

SYI
Isoleucine--tRNA ligase

2

12

High-throughput

0.611

High

395084

DNAA
Chromosomal replication initiator protein DnaA

2

1

High-throughput

0.611

High

437531

TSAD
tRNA N6-adenosine threonylcarbamoyltransferase

2

1

High-throughput

0.611

High

490347

HSLU
ATP-dependent protease ATPase subunit HslU

2

5

High-throughput

0.611

High

501122

RHO
Transcription termination factor Rho

2

5

High-throughput

0.611

High

506252

LPXB
Lipid-A-disaccharide synthase

2

1

High-throughput

0.611

High

506253

DPO3A
DNA polymerase III subunit alpha

2

1

High-throughput

0.611

High

506263

RNE
Ribonuclease E

2

1

High-throughput

0.611

High

506265

MUKB
Chromosome partition protein MukB

2

3

High-throughput

0.611

High

506286

RLMN
Dual-specificity RNA methyltransferase RlmN

2

2

High-throughput

0.611

High

506292

HRPA
ATP-dependent RNA helicase HrpA

2

2

High-throughput

0.611

High

506313

DXS
1-deoxy-D-xylulose-5-phosphate synthase

2

3

High-throughput

0.611

High

491638

KPRS
Ribose-phosphate pyrophosphokinase

2

3

High-throughput

0.594

High

490890

HFQ
RNA-binding protein Hfq

2

1

High-throughput

0.588

High

495123

UBIE
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

2

3

High-throughput

0.588

High

495912

RPOB
DNA-directed RNA polymerase subunit beta

2

5

High-throughput

0.588

High

496905

LON
Lon protease

2

5

High-throughput

0.588

High

497274

ULAR
HTH-type transcriptional regulator UlaR

2

1

High-throughput

0.588

High

498341

FTSA
Cell division protein FtsA

2

12

High-throughput

0.588

High

500134

UVRY
Response regulator UvrY

2

3

High-throughput

0.588

High

500424

GYRA
DNA gyrase subunit A

2

1

High-throughput

0.588

High

501512

SRP54
Signal recognition particle protein

2

2

High-throughput

0.588

High

506298

CLPB
Chaperone protein ClpB

2

7

High-throughput

0.588

High

368499

XYLA
Xylose isomerase

2

1

High-throughput

0.571

High

450367

SYV
Valine--tRNA ligase

2

12

High-throughput

0.571

High

473294

DNAJ
Chaperone protein DnaJ

2

7

High-throughput

0.571

High

496012

YIDA
Sugar phosphatase YidA

2

1

High-throughput

0.571

High

498384

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

2

9

High-throughput

0.571

High

506272

ACRF
Multidrug export protein AcrF

2

1

High-throughput

0.571

High

506287

FBPC
Fe(3+) ions import ATP-binding protein FbpC

2

9

High-throughput

0.571

High

506302

CUTA
Divalent-cation tolerance protein CutA

2

1

High-throughput

0.571

High

506317

YAJL
Protein/nucleic acid deglycase 3

2

2

Small-scale

0.571

High

506251

SECA
Protein translocase subunit SecA

1

1

High-throughput

0.561

High

506256

RPOS
RNA polymerase sigma factor RpoS

1

1

High-throughput

0.561

High

506260

MURC
UDP-N-acetylmuramate--L-alanine ligase

1

1

High-throughput

0.561

High

395119

DPO3E
DNA polymerase III subunit epsilon

2

2

High-throughput

0.558

High

450016

MALT
HTH-type transcriptional regulator MalT

2

1

High-throughput

0.558

High

495471

YBED
UPF0250 protein YbeD

2

1

High-throughput

0.558

High

498949

DNAB
Replicative DNA helicase DnaB

2

3

High-throughput

0.558

High

506257

HELD
DNA helicase IV

2

5

High-throughput

0.558

High

506262

SRMB
ATP-dependent RNA helicase SrmB

2

8

High-throughput

0.558

High

506271

MUTS
DNA mismatch repair protein MutS

2

4

High-throughput

0.558

High

506273

FDNG
Formate dehydrogenase, nitrate-inducible, major subunit

2

3

High-throughput

0.558

High

506274

HYPD
Hydrogenase maturation factor HypD

2

1

High-throughput

0.558

High

506293

UBIU
Ubiquinone biosynthesis protein UbiU

2

2

High-throughput

0.558

High

506296

CAN
Carbonic anhydrase 2

2

1

High-throughput

0.558

High

506305

YBJX
Uncharacterized protein YbjX

2

1

High-throughput

0.558

High

506316

UACR
Putative uric acid sigma-54-dependent transcriptional regulator UacR

2

1

High-throughput

0.558

High

490482

HSCB
Co-chaperone protein HscB

2

1

High-throughput

0.537

High

501882

RLME
Ribosomal RNA large subunit methyltransferase E

2

1

High-throughput

0.537

High

505907

GATY
D-tagatose-1,6-bisphosphate aldolase subunit GatY

2

1

High-throughput

0.537

High

420147

KDSB
3-deoxy-manno-octulosonate cytidylyltransferase

1

1

High-throughput

0.536

High

480545

GRPE
Protein GrpE

1

2

High-throughput

0.536

High

490983

HSLO
33 kDa chaperonin

1

1

High-throughput

0.536

High

492135

HSLV
ATP-dependent protease subunit HslV

1

1

High-throughput

0.536

High

494294

RS5
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

506249

RNPH
Truncated inactive ribonuclease PH

1

8

High-throughput

0.536

High

506277

MOAA
GTP 3',8-cyclase

1

1

High-throughput

0.536

High

506279

GLMM
Phosphoglucosamine mutase

1

1

High-throughput

0.536

High

506282

NIKD
Nickel import ATP-binding protein NikD

1

14

High-throughput

0.536

High

506285

CBPA
Curved DNA-binding protein

1

4

High-throughput

0.536

High

506297

RISB
6,7-dimethyl-8-ribityllumazine synthase

1

1

High-throughput

0.536

High

506308

DMLA
D-malate dehydrogenase [decarboxylating]

1

4

High-throughput

0.536

High

506311

DGCM
Diguanylate cyclase DgcM

1

2

High-throughput

0.536

High

495425

YAAA
DNA-binding and peroxide stress resistance protein YaaA

2

1

High-throughput

0.521

High

506314

YDHQ
Protein YdhQ

2

1

High-throughput

0.521

High

506290

RSGA
Small ribosomal subunit biogenesis GTPase RsgA

1

0

High-throughput

0.513

High

506312

YQAB
Fructose-1-phosphate phosphatase YqaB

1

0

High-throughput

0.513

High

361588

RIR1
Ribonucleoside-diphosphate reductase 1 subunit alpha

1

2

High-throughput

0.489

High

365832

RPOD
RNA polymerase sigma factor RpoD

1

1

High-throughput

0.489

High

368822

SYA
Alanine--tRNA ligase

1

3

High-throughput

0.489

High

469906

USG
USG-1 protein

1

1

High-throughput

0.489

High

479542

NARG
Respiratory nitrate reductase 1 alpha chain

1

3

High-throughput

0.489

High

506254

NARH
Respiratory nitrate reductase 1 beta chain

1

2

High-throughput

0.489

High

506264

RECJ
Single-stranded-DNA-specific exonuclease RecJ

1

1

High-throughput

0.489

High

506266

MURI
Glutamate racemase

1

1

High-throughput

0.489

High

506270

YICC
Endoribonuclease YicC

1

1

High-throughput

0.489

High

506276

PEPT
Peptidase T

1

1

High-throughput

0.489

High

506291

YJJV
Uncharacterized metal-dependent hydrolase YjjV

1

2

High-throughput

0.489

High

506300

YHES
Probable ATP-binding protein YheS

1

7

High-throughput

0.489

High

506307

RLHA
23S rRNA 5-hydroxycytidine C2501 synthase

1

2

High-throughput

0.489

High

506309

YOAA
ATP-dependent DNA helicase YoaA

1

1

High-throughput

0.489

High

490676

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

1

High-throughput

0.484

High

491113

DNAK
Chaperone protein DnaK

1

7

High-throughput

0.484

High

491720

KTHY
Thymidylate kinase

1

2

High-throughput

0.484

High

492039

PLSB
Glycerol-3-phosphate acyltransferase

1

1

High-throughput

0.484

High

492073

IPYR
Inorganic pyrophosphatase

1

4

High-throughput

0.484

High

492169

PTH
Peptidyl-tRNA hydrolase

1

1

High-throughput

0.484

High

494740

METK
S-adenosylmethionine synthase

1

1

High-throughput

0.484

High

495660

SYK2
Lysine--tRNA ligase, heat inducible

1

10

High-throughput

0.484

High

496432

FTSZ
Cell division protein FtsZ

1

4

High-throughput

0.484

High

497204

FTSE
Cell division ATP-binding protein FtsE

1

8

High-throughput

0.484

High

497340

MREB
Cell shape-determining protein MreB

1

13

High-throughput

0.484

High

497790

PSTB
Phosphate import ATP-binding protein PstB

1

7

High-throughput

0.484

High

499025

MBHM
Hydrogenase-2 large chain

1

2

High-throughput

0.484

High

499038

HINT
Purine nucleoside phosphoramidase

1

2

High-throughput

0.484

High

500448

GYRB
DNA gyrase subunit B

1

1

High-throughput

0.484

High

500705

NUSA
Transcription termination/antitermination protein NusA

1

1

High-throughput

0.484

High

501704

IBPA
Small heat shock protein IbpA

1

2

High-throughput

0.484

High

501730

IBPB
Small heat shock protein IbpB

1

2

High-throughput

0.484

High

506299

MLAF
Intermembrane phospholipid transport system ATP-binding protein MlaF

1

13

High-throughput

0.484

High

506304

RIR2
Ribonucleoside-diphosphate reductase 1 subunit beta

1

1

High-throughput

0.484

High

506275

METQ
D-methionine-binding lipoprotein MetQ

1

0

High-throughput

0.479

High

450063

POXB
Pyruvate dehydrogenase [ubiquinone]

1

2

High-throughput

0.479

High

483716

PUTA
Bifunctional protein PutA [Includes: Proline dehydrogenase

1

5

High-throughput

0.479

High

489639

CH60
Chaperonin GroEL

1

1

Small-scale

0.479

High

491865

NAGB
Glucosamine-6-phosphate deaminase

1

2

High-throughput

0.479

High

496214

ALAA
Glutamate-pyruvate aminotransferase AlaA

1

1

High-throughput

0.479

High

497859

FDNH
Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit

1

2

High-throughput

0.479

High

506259

PRIA
Replication restart protein PriA

1

6

High-throughput

0.479

High

506306

LOLD
Lipoprotein-releasing system ATP-binding protein LolD

1

9

High-throughput

0.479

High

495142

RAPZ
RNase adapter protein RapZ

1

0

High-throughput

0.464

High

496629

LDCI
Inducible lysine decarboxylase

1

0

High-throughput

0.464

High

501035

SSPB
Stringent starvation protein B

1

0

High-throughput

0.464

High

393892

PBPA
Penicillin-binding protein 1A

1

0

High-throughput

0.458

High

491410

HYPA
Hydrogenase maturation factor HypA

1

0

High-throughput

0.458

High

496168

RIMI
[Ribosomal protein bS18]-alanine N-acetyltransferase

1

0

High-throughput

0.458

High

499457

LAPA
Lipopolysaccharide assembly protein A

1

0

High-throughput

0.458

High

500991

RMF
Ribosome modulation factor

1

0

High-throughput

0.458

High

501640

YHBY
RNA-binding protein YhbY

1

0

High-throughput

0.458

High

506258

MURG
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

1

0

High-throughput

0.458

High

449908

CCA
Multifunctional CCA protein [Includes: CCA-adding enzyme

1

1

High-throughput

0.445

High

469925

RECB
RecBCD enzyme subunit RecB

1

3

High-throughput

0.445

High

490820

GREA
Transcription elongation factor GreA

1

1

High-throughput

0.445

High

493759

RS2
Small ribosomal subunit protein uS2

1

5

High-throughput

0.445

High

495485

RHLB
ATP-dependent RNA helicase RhlB

1

5

High-throughput

0.445

High

506250

RCSB
Transcriptional regulatory protein RcsB

1

3

High-throughput

0.445

High

506280

RAVA
Regulatory ATPase RavA

1

10

High-throughput

0.445

High

506284

YEJF
Uncharacterized ABC transporter ATP-binding protein YejF

1

15

High-throughput

0.445

High

506289

USPG
Universal stress protein UP12

1

1

High-throughput

0.445

High

506295

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.445

High

490262

CLPP
ATP-dependent Clp protease proteolytic subunit

1

2

High-throughput

0.442

High

490648

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

1

High-throughput

0.442

High

491550

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

1

High-throughput

0.442

High

491813

MURA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

1

2

High-throughput

0.442

High

494723

RUVB
Holliday junction branch migration complex subunit RuvB

1

7

High-throughput

0.442

High

495194

PSRP
Phosphoenolpyruvate synthase regulatory protein

1

1

High-throughput

0.442

High

496954

PTA
Phosphate acetyltransferase

1

1

High-throughput

0.442

High

499363

CRA
Catabolite repressor/activator

1

2

High-throughput

0.442

High

500254

MIAB
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase

1

1

High-throughput

0.442

High

486848

GLTD
Glutamate synthase [NADPH] small chain

1

1

High-throughput

0.437

High

500945

YCFH
Uncharacterized metal-dependent hydrolase YcfH

1

2

High-throughput

0.437

High

506267

ISPA
Farnesyl diphosphate synthase

1

1

High-throughput

0.437

High

506268

MUTL
DNA mismatch repair protein MutL

1

2

High-throughput

0.437

High

506278

METN
Methionine import ATP-binding protein MetN

1

11

High-throughput

0.437

High

368959

SYGA
Glycine--tRNA ligase alpha subunit

1

1

High-throughput

0.407

High

490309

CLPX
ATP-dependent Clp protease ATP-binding subunit ClpX

1

9

High-throughput

0.407

High

501520

SSB
Single-stranded DNA-binding protein

1

2

High-throughput

0.407

High

506283

NIKE
Nickel import ATP-binding protein NikE

1

13

High-throughput

0.407

High

499854

RSMD
Ribosomal RNA small subunit methyltransferase D

2

0

High-throughput

0.318

High

506255

TDCD
Propionate kinase

2

0

High-throughput

0.318

High

506315

QUEC
7-cyano-7-deazaguanine synthase

2

0

High-throughput

0.318

High

491393

NIKR
Nickel-responsive regulator

1

0

High-throughput

0.279

Low

506261

PNCB
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.279

Low

506281

NIKA
Nickel-binding periplasmic protein

1

0

High-throughput

0.279

Low

506288

PTKB
PTS system galactitol-specific EIIB component

1

0

High-throughput

0.279

Low

506294

ABPB
Anti-bacteriophage protein B

1

0

High-throughput

0.279

Low

506310

LYSAC
Peptidyl-lysine N-acetyltransferase PatZ

1

0

High-throughput

0.279

Low

492247

PYRH
Uridylate kinase

1

0

High-throughput

0.253

Low

495771

ARGP
HTH-type transcriptional regulator ArgP

1

0

High-throughput

0.253

Low

498167

END3
Endonuclease III

1

0

High-throughput

0.253

Low

498557

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.253

Low

499756

VIAA
Regulatory protein ViaA

1

0

High-throughput

0.253

Low

500057

CEDA
Cell division activator CedA

1

0

High-throughput

0.253

Low

501099

SPOT
Bifunctional

1

0

High-throughput

0.253

Low

506301

YDIH
Uncharacterized protein YdiH

1

0

High-throughput

0.253

Low

506269

PHOP
Transcriptional regulatory protein PhoP

1

0

High-throughput

0.249

Low

506303

MBHS
Hydrogenase-1 small chain

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025