HitPredict

Interactor 1: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.792

Property	Details
Experiments	25505247, 10585430
Identification Methods	unspecified method, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 258
+	Rn
		70070 GHR_RAT (1-637): 0: 749: 69.80		B1WBX9_RAT (1-258): 3.95e-68: 212: 90.31
+	Hs
		146586 GHR_HUMAN (1-638): 0: 731: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147382 GHR_HUMAN (1-638): 0: 731: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		181779 GHR_HUMAN (1-638): 0: 731: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Mm
		562609 GHR_MOUSE (1-637): 0: 748: 67.85		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		500960 GHR_HUMAN (1-638): 0: 731: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		500948 GHR_HUMAN (1-638): 0: 731: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129180 GHR_HUMAN (1-638): 0: 731: 100.00		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		560479 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		146590 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147385 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		562584 IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		560475 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		146591 IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		411991 IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		181790 IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Mm
		540265 EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86		LYN_MOUSE (47-215): 6.97e-40: 146: 16.38
+	Mm
		193372 EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86		SOCS3_MOUSE (43-254): 1.24e-40: 141: 29.77
+	Hs
		562513 IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Mm
		540266 EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86		P85A_MOUSE (52-188): 4.14e-21: 94.1: 16.06