HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27684187, 30472188, 31501420
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 504
+	Hs
		125115 HSP7C_HUMAN (26-637): 0: 916: 66.02		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		125114 BIP_HUMAN (19-654): 0: 914: 100.00		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		504580 HSP7C_HUMAN (26-637): 0: 916: 66.02		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		504792 HSP7C_HUMAN (26-637): 0: 916: 66.02		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		713923 HS71L_HUMAN (24-647): 0: 922: 63.16		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		502449 BIP_HUMAN (19-654): 0: 914: 100.00		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		502570 BIP_HUMAN (19-654): 0: 914: 100.00		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		503644 HSP7C_HUMAN (26-637): 0: 916: 66.02		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		564032 HSP76_HUMAN (25-635): 0: 915: 62.54		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808427 HSP72_HUMAN (25-636): 0: 905: 64.51		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Dm
		89881 BIP_DROME (27-654): 0: 989: 82.86		D5SHR3_DROME (258-504): 1.07e-52: 186: 11.60
+	Dm
		669807 BIP_DROME (27-654): 0: 989: 82.86		YAP1_DROME (52-268): 1.16e-44: 163: 29.25
+	Sc
		560672 BIP_YEAST (22-638): 0: 798: 68.82		RSP5_YEAST (3-504): 1.79e-105: 334: 15.25
+	Hs
		564179 HSP76_HUMAN (25-635): 0: 915: 62.54		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		502532 BIP_HUMAN (19-654): 0: 914: 100.00		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		502197 BIP_HUMAN (19-654): 0: 914: 100.00		MAGI3_HUMAN (69-270): 5.85e-40: 156: 21.64
+	Hs
		504871 HSP7C_HUMAN (26-637): 0: 916: 66.02		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Sc
		560780 BIP_YEAST (22-638): 0: 798: 68.82		TOM1_YEAST (261-504): 2.18e-46: 176: 11.34
+	Pf
		1211395 Q8I2X4_PLAF7 (3-654): 0: 780: 65.04		Q8IB94_PLAF7 (258-502): 4.68e-42: 163: 10.57