Protein: CO3
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b (Complement C3b-alpha' chain); Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]

Gene: CO3, C3
Organism: Homo sapiens
Interactions: 174
UniProt ID: P01024

Gene Ontology (top 5):
GO:0001798 - positive regulation of type IIa hypersensitivity
GO:0001934 - positive regulation of protein phosphorylation
GO:0001970 - positive regulation of activation of membrane attack complex
GO:0002430 - complement receptor mediated signaling pathway
GO:0004866 - endopeptidase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369813

CFAH
Complement factor H

8

17

Small-scale

0.971

High

369823

MCP
Membrane cofactor protein

5

20

Small-scale

0.915

High

369806

CFAI
Complement factor I

4

1

Small-scale

0.873

High

369831

CR2
Complement receptor type 2

3

19

Small-scale

0.867

High

369900

FHR4
Complement factor H-related protein 4

3

20

Small-scale

0.853

High

366559

CFAB
Complement factor B

3

12

Small-scale

0.834

High

369836

PROP
Properdin

2

2

Small-scale

0.778

High

369832

ITAX
Integrin alpha-X

2

7

Small-scale

0.768

High

132962

MATN2
Matrilin-2

1

3

High-throughput

0.691

High

210640

KLK10
Kallikrein-10

1

8

High-throughput

0.691

High

369828

CR1
Complement receptor type 1

1

20

Small-scale

0.691

High

369838

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.691

High

369883

GP141
Probable G-protein coupled receptor 141

1

6

High-throughput

0.691

High

369936

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

Small-scale

0.690

High

369796

CO5
Complement C5

1

4

Small-scale

0.647

High

369859

FHR3
Complement factor H-related protein 3

1

20

Small-scale

0.647

High

369860

FHR1
Complement factor H-related protein 1

1

18

Small-scale

0.647

High

369916

FHR5
Complement factor H-related protein 5

1

19

Small-scale

0.647

High

369871

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.628

High

369907

SNX27
Sorting nexin-27

2

2

High-throughput

0.628

High

254712

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

2

3

High-throughput

0.618

High

369795

CO3
Complement C3

1

4

Small-scale

0.618

High

369812

CATG
Cathepsin G

1

8

Small-scale

0.618

High

369816

CO4A
Complement C4-A

1

4

High-throughput

0.618

High

369819

ITAM
Integrin alpha-M

1

5

Small-scale

0.618

High

369861

ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3

1

3

High-throughput

0.618

High

369868

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

1

High-throughput

0.618

High

369890

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.609

High

351498

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

4

High-throughput

0.606

High

369934

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

352819

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.580

High

369870

K1H1
Keratin, type I cuticular Ha1

2

0

High-throughput

0.580

High

125800

MASP2
Mannan-binding lectin serine protease 2

1

8

Small-scale

0.575

High

369807

F13B
Coagulation factor XIII B chain

1

18

Small-scale

0.575

High

369845

MASP1
Mannan-binding lectin serine protease 1

1

7

Small-scale

0.575

High

369908

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.574

High

369876

MYOME
Myomegalin

2

4

High-throughput

0.558

High

65003

GG6L9
Golgin subfamily A member 6-like protein 9

2

4

High-throughput

0.553

High

369850

KR108
Keratin-associated protein 10-8

2

2

High-throughput

0.553

High

369817

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.552

High

194436

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.536

High

351628

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

369821

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

369826

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

369829

LEG3
Galectin-3

1

7

High-throughput

0.536

High

369848

STX17
Syntaxin-17

1

4

High-throughput

0.536

High

369873

FNDC1
Fibronectin type III domain-containing protein 1

1

2

High-throughput

0.536

High

369881

CRDL2
Chordin-like protein 2

1

2

High-throughput

0.536

High

369884

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.536

High

369892

FNDC5
Fibronectin type III domain-containing protein 5

1

3

High-throughput

0.536

High

369898

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

369903

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

369912

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.536

High

369915

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

369932

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

2

High-throughput

0.536

High

369879

A16L1
Autophagy-related protein 16-1

2

4

Small-scale

0.534

High

105064

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

369804

ITB2
Integrin beta-2

1

2

Small-scale

0.527

High

369846

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.513

High

369858

ANK2
Ankyrin-2

1

0

High-throughput

0.513

High

369867

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

369814

HMGB1
High mobility group protein B1

1

7

High-throughput

0.508

High

369810

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.501

High

369822

CBPN
Carboxypeptidase N catalytic chain

1

3

Small-scale

0.501

High

369866

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.500

High

369811

FUMH
Fumarate hydratase, mitochondrial

1

0

Small-scale

0.493

High

231360

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

325251

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.489

High

331616

MBD4
Methyl-CpG-binding domain protein 4

1

3

High-throughput

0.489

High

369820

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.489

High

369849

DSCR6
Protein ripply3

1

2

High-throughput

0.489

High

369857

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.489

High

369872

CR021
UPF0711 protein C18orf21

1

3

High-throughput

0.489

High

369878

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

369880

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

369885

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

369888

NRSN1
Neurensin-1

1

3

High-throughput

0.489

High

369896

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

369902

PIGT
GPI-anchor transamidase component PIGT

1

3

High-throughput

0.489

High

369905

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.489

High

369911

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

369914

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.489

High

369921

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.489

High

369923

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.489

High

369931

PHF11
PHD finger protein 11

1

5

High-throughput

0.489

High

369938

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.489

High

369833

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.481

High

162763

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

2

High-throughput

0.479

High

369798

FINC
Fibronectin

1

5

Small-scale

0.479

High

369800

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

369805

IC1
Plasma protease C1 inhibitor

1

1

High-throughput

0.479

High

369815

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.479

High

369824

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.479

High

369827

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

369840

MYH10
Myosin-10

1

1

High-throughput

0.479

High

369854

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

369869

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

369893

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.479

High

369899

TITIN
Titin

1

3

High-throughput

0.479

High

369901

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

369906

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.479

High

369924

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

369940

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

136763

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

369230

ANT3
Antithrombin-III

1

0

High-throughput

0.458

High

369799

TRFE
Serotransferrin

1

0

High-throughput

0.458

High

369802

HRG
Histidine-rich glycoprotein

1

0

High-throughput

0.458

High

369808

PERM
Myeloperoxidase

1

0

Small-scale

0.458

High

369835

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.458

High

369837

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

369841

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

369847

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

369855

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.458

High

369925

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.458

High

369929

BIN2
Bridging integrator 2

1

0

High-throughput

0.458

High

369939

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.458

High

73757

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

1

High-throughput

0.445

High

229254

ANGL7
Angiopoietin-related protein 7

1

1

High-throughput

0.445

High

261042

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.445

High

369797

IGHM
Immunoglobulin heavy constant mu

1

1

High-throughput

0.445

High

369818

CLUS
Clusterin

1

1

High-throughput

0.445

High

369862

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

369897

CA054
Uncharacterized protein C1orf54

1

1

High-throughput

0.445

High

369913

PKP2
Plakophilin-2

1

5

High-throughput

0.445

High

369937

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

240438

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.437

High

277224

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

360698

COX3
Cytochrome c oxidase subunit 3

1

3

Small-scale

0.437

High

369803

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

369830

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.437

High

369834

H2B1O
Histone H2B type 1-O

1

3

High-throughput

0.437

High

369842

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.437

High

369843

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.437

High

369851

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

369853

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

369863

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

369864

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.437

High

369877

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.437

High

369882

ASXL2
Putative Polycomb group protein ASXL2

1

4

High-throughput

0.437

High

369886

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.437

High

369917

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

369922

ANLN
Anillin

1

2

High-throughput

0.437

High

369926

RNF12
E3 ubiquitin-protein ligase RLIM

1

7

High-throughput

0.437

High

369927

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.437

High

369930

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

369801

PRIO
Major prion protein

1

0

High-throughput

0.426

High

369865

CUL3
Cullin-3

1

0

High-throughput

0.426

High

369887

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

369894

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

369889

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.407

High

369909

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.407

High

369891

ASCC1
Activating signal cointegrator 1 complex subunit 1

3

0

High-throughput

0.347

High

369825

ZSC20
Zinc finger and SCAN domain-containing protein 20

2

0

High-throughput

0.328

High

369839

CAH8
Carbonic anhydrase-related protein

2

0

High-throughput

0.328

High

369918

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

369919

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

158083

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.279

Low

369844

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

369856

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.279

Low

369895

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.279

Low

369920

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

369933

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

369935

ING4
Inhibitor of growth protein 4

1

0

High-throughput

0.279

Low

238337

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

291171

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

369910

EYA1
Protein phosphatase EYA1

1

0

High-throughput

0.249

Low

219584

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.232

Low

369809

DCUP
Uroporphyrinogen decarboxylase

1

0

High-throughput

0.232

Low

369852

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.232

Low

369874

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

369875

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

369904

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

369928

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025