HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23443559
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0030496 - midbody
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 344
+	Dm
		669813 BIP_DROME (27-654): 0: 989: 82.86		AKT1_DROME (3-343): 2.15e-133: 394: 28.01
+	Hs
		503528 HSP7C_HUMAN (26-637): 0: 916: 66.02		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		564016 HSP76_HUMAN (25-635): 0: 915: 62.54		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		501740 BIP_HUMAN (19-654): 0: 914: 100.00		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		160349 HSP7C_HUMAN (26-637): 0: 916: 66.02		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		160348 BIP_HUMAN (19-654): 0: 914: 100.00		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		503439 HSP7C_HUMAN (26-637): 0: 916: 66.02		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		160460 HSP72_HUMAN (25-636): 0: 905: 64.51		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89