Protein: H2A1
Histone H2A.1

Gene: H2A1, HTA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 241
UniProt ID: P04911

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

380908

H2B1
Histone H2B.1

20

20

Small-scale

0.986

High

419363

NAP1
Nucleosome assembly protein

16

14

Small-scale

0.984

High

419463

IMB5
Importin subunit beta-5

13

9

Small-scale

0.981

High

419388

SPT16
FACT complex subunit SPT16

13

9

Small-scale

0.979

High

419484

H3
Histone H3

13

20

Small-scale

0.975

High

381770

H4
Histone H4

11

15

Small-scale

0.971

High

419502

POB3
FACT complex subunit POB3

7

11

Small-scale

0.963

High

381344

H2B2
Histone H2B.2

7

20

Small-scale

0.951

High

419536

H2AZ
Histone H2A.Z

6

19

Small-scale

0.950

High

419524

ESA1
Histone acetyltransferase ESA1

6

13

Small-scale

0.937

High

419403

CENPA
Histone H3-like centromeric protein CSE4

6

20

Small-scale

0.925

High

419505

SWR1
Helicase SWR1

5

20

Small-scale

0.915

High

419312

H2A2
Histone H2A.2

5

20

Small-scale

0.903

High

419465

INO80
Chromatin-remodeling ATPase INO80

4

20

Small-scale

0.878

High

419358

RPC2
DNA-directed RNA polymerase III subunit RPC2

3

3

High-throughput

0.847

High

419380

FUN30
ATP-dependent helicase FUN30

3

20

Small-scale

0.840

High

419382

IMB3
Importin subunit beta-3

3

7

Small-scale

0.840

High

419509

IMB1
Importin subunit beta-1

3

5

Small-scale

0.840

High

419319

SIR3
Regulatory protein SIR3

3

7

Small-scale

0.839

High

419377

MCM2
DNA replication licensing factor MCM2

3

20

Small-scale

0.834

High

419311

H2A1
Histone H2A.1

2

20

Small-scale

0.825

High

419482

ORC1
Origin recognition complex subunit 1

2

8

Small-scale

0.799

High

419414

IMB2
Importin subunit beta-2

2

6

Small-scale

0.778

High

419434

IMB4
Importin subunit beta-4

2

8

Small-scale

0.778

High

419519

BRE1
E3 ubiquitin-protein ligase BRE1

2

18

Small-scale

0.778

High

419494

VPS72
Vacuolar protein sorting-associated protein 72

2

1

Small-scale

0.754

High

419398

SAS3
Histone acetyltransferase SAS3

1

11

Small-scale

0.691

High

419512

PDP3
NuA3 HAT complex component PDP3

1

5

Small-scale

0.691

High

419516

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

20

High-throughput

0.691

High

419485

ARP4
Actin-related protein 4

3

9

Small-scale

0.672

High

419383

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

3

6

Small-scale

0.662

High

419411

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

3

1

Small-scale

0.656

High

419527

PSH1
RING finger protein PSH1

3

6

Small-scale

0.656

High

419349

CBF1
Centromere-binding protein 1

1

3

Small-scale

0.647

High

419350

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

4

Small-scale

0.647

High

419356

SNF2
Transcription regulatory protein SNF2

1

20

Small-scale

0.647

High

419391

CHD1
Chromo domain-containing protein 1

1

20

Small-scale

0.647

High

419410

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

Small-scale

0.647

High

419457

JHD2
Histone demethylase JHD2

1

1

Small-scale

0.647

High

419476

VPS75
Vacuolar protein sorting-associated protein 75

1

16

Small-scale

0.647

High

419481

HDA1
Histone deacetylase HDA1

1

13

Small-scale

0.647

High

419497

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

Small-scale

0.647

High

419528

SCM3
Protein SCM3

1

1

Small-scale

0.647

High

419493

GCN5
Histone acetyltransferase GCN5

3

20

Small-scale

0.633

High

419529

HIF1
HAT1-interacting factor 1

2

1

Small-scale

0.625

High

419365

RNA14
mRNA 3'-end-processing protein RNA14

2

6

High-throughput

0.621

High

419437

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

2

1

Small-scale

0.621

High

419471

RT102
Regulator of Ty1 transposition protein 102

2

1

Small-scale

0.619

High

419508

UTP13
U3 small nucleolar RNA-associated protein 13

1

11

High-throughput

0.618

High

419515

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.618

High

419318

SIR2
NAD-dependent histone deacetylase SIR2

1

10

Small-scale

0.618

High

419323

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.618

High

419381

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.618

High

419409

GBLP
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.618

High

419461

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

1

Small-scale

0.618

High

419525

NEW1
[NU+] prion formation protein 1

1

4

High-throughput

0.618

High

419533

CMR1
DNA damage-binding protein CMR1

1

12

High-throughput

0.618

High

419342

RAD9
DNA repair protein RAD9

2

1

Small-scale

0.613

High

419418

CENPU
Inner kinetochore subunit AME1

3

0

Small-scale

0.613

High

402168

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

6

High-throughput

0.611

High

419384

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

2

High-throughput

0.611

High

419531

ARP7
Actin-related protein 7

2

9

High-throughput

0.611

High

419397

NCBP1
Nuclear cap-binding protein complex subunit 1

2

0

High-throughput

0.595

High

419355

RCC1
Guanine nucleotide exchange factor SRM1

2

5

Small-scale

0.595

High

419371

RFA2
Replication factor A protein 2

2

4

Small-scale

0.595

High

419480

ARP5
Actin-related protein 5

2

8

Small-scale

0.595

High

419495

RUVB1
RuvB-like protein 1

2

9

Small-scale

0.595

High

419439

ATAD2
ATPase histone chaperone YTA7

2

4

Small-scale

0.594

High

419334

NHP6A
Non-histone chromosomal protein 6A

2

20

Small-scale

0.594

High

419361

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

2

4

High-throughput

0.588

High

419419

SWC5
SWR1-complex protein 5

2

5

Small-scale

0.585

High

419379

MCM4
DNA replication licensing factor MCM4

2

20

Small-scale

0.584

High

419467

SWC4
SWR1-complex protein 4

2

1

Small-scale

0.584

High

419530

ARP8
Actin-like protein ARP8

2

8

Small-scale

0.584

High

419422

YNG2
Chromatin modification-related protein YNG2

1

13

Small-scale

0.575

High

419447

EPL1
Enhancer of polycomb-like protein 1

2

1

Small-scale

0.571

High

419488

ADA2
SAGA complex subunit ADA2

2

7

Small-scale

0.571

High

419436

IES2
Ino eighty subunit 2

2

0

Small-scale

0.569

High

419496

CTK1
CTD kinase subunit alpha

1

8

Small-scale

0.561

High

419345

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.536

High

419386

HIR2
Protein HIR2

1

8

High-throughput

0.536

High

419408

NOP4
Nucleolar protein 4

1

10

High-throughput

0.536

High

419428

FKHL1
Pre-rRNA-processing protein FHL1

1

3

High-throughput

0.536

High

419468

PESC
Pescadillo homolog

1

1

High-throughput

0.536

High

419486

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

19

High-throughput

0.536

High

419517

RSC3
Chromatin structure-remodeling complex protein RSC3

1

2

High-throughput

0.536

High

419523

DNLI4
DNA ligase 4

1

4

High-throughput

0.536

High

419335

NHP6B
Non-histone chromosomal protein 6B

1

20

Small-scale

0.527

High

419426

RT107
Regulator of Ty1 transposition protein 107

1

8

Small-scale

0.516

High

419521

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

419348

FUS3
Mitogen-activated protein kinase FUS3

1

3

High-throughput

0.501

High

419354

REB1
DNA-binding protein REB1

1

2

Small-scale

0.501

High

419390

SWI3
SWI/SNF complex subunit SWI3

1

12

Small-scale

0.501

High

419399

TAF14
Transcription initiation factor TFIID subunit 14

1

3

Small-scale

0.501

High

419416

HSL7
Protein arginine N-methyltransferase HSL7

1

3

Small-scale

0.501

High

419433

IES5
Ino eighty subunit 5

1

1

Small-scale

0.501

High

419473

SNF12
Transcription regulatory protein SNF12

1

3

Small-scale

0.501

High

419477

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

20

Small-scale

0.501

High

419483

ACT
Actin

1

5

Small-scale

0.501

High

419532

RUVB2
RuvB-like protein 2

1

9

Small-scale

0.501

High

419330

SSBP1
Single-stranded nucleic acid-binding protein

1

9

High-throughput

0.500

High

419347

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.500

High

419357

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.500

High

419407

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.489

High

419445

KRI1
Protein KRI1

1

5

High-throughput

0.489

High

419474

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

408374

GAL4
Regulatory protein GAL4

1

2

Small-scale

0.481

High

419425

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

149181

FOB1
DNA replication fork-blocking protein FOB1

1

1

Small-scale

0.479

High

401797

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.479

High

415186

TOP1
DNA topoisomerase 1

1

4

Small-scale

0.479

High

419314

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

419316

KAPA
cAMP-dependent protein kinase type 1

1

7

Small-scale

0.479

High

419320

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

1

High-throughput

0.479

High

419322

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.479

High

419337

RAP1
DNA-binding protein RAP1

1

1

High-throughput

0.479

High

419341

TBP
TATA-box-binding protein

1

1

High-throughput

0.479

High

419346

DPOG
DNA polymerase gamma

1

1

High-throughput

0.479

High

419352

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.479

High

419353

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

419359

RFA1
Replication factor A protein 1

1

4

Small-scale

0.479

High

419362

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.479

High

419364

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

419372

RFA3
Replication factor A protein 3

1

1

High-throughput

0.479

High

419374

SPT5
Transcription elongation factor SPT5

1

6

Small-scale

0.479

High

419375

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

419376

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

419378

RIF1
Telomere length regulator protein RIF1

1

1

High-throughput

0.479

High

419392

KU70
ATP-dependent DNA helicase II subunit 1

1

9

High-throughput

0.479

High

419393

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

2

High-throughput

0.479

High

419394

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

6

High-throughput

0.479

High

419400

CENPC
Inner kinetochore subunit MIF2

1

1

Small-scale

0.479

High

419401

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.479

High

419406

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

1

High-throughput

0.479

High

419412

HEK2
Heterogeneous nuclear rnp K-like protein 2

1

5

High-throughput

0.479

High

419413

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

1

High-throughput

0.479

High

419417

EXO5
Exonuclease V, mitochondrial

1

1

High-throughput

0.479

High

419421

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

419423

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

10

Small-scale

0.479

High

419430

RSP5
E3 ubiquitin-protein ligase RSP5

1

7

High-throughput

0.479

High

419444

REF2
RNA end formation protein 2

1

1

High-throughput

0.479

High

419448

IES1
Ino eighty subunit 1

1

1

Small-scale

0.479

High

419451

CTK2
CTD kinase subunit beta

1

1

Small-scale

0.479

High

419453

SMC3
Structural maintenance of chromosomes protein 3

1

5

High-throughput

0.479

High

419454

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

1

High-throughput

0.479

High

419455

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

419462

RTF1
RNA polymerase-associated protein RTF1

1

1

Small-scale

0.479

High

419464

VID30
GID complex subunit 1

1

7

High-throughput

0.479

High

419479

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

419489

ABF2
ARS-binding factor 2, mitochondrial

1

20

High-throughput

0.479

High

419491

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

1

High-throughput

0.479

High

419492

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

419499

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.479

High

419500

KU80
ATP-dependent DNA helicase II subunit 2

1

9

High-throughput

0.479

High

419504

TRI1
Protein TRI1

1

4

High-throughput

0.479

High

419506

HRQ1
ATP-dependent helicase HRQ1

1

6

Small-scale

0.479

High

419507

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

1

High-throughput

0.479

High

419518

BDF2
Bromodomain-containing factor 2

1

20

High-throughput

0.479

High

419520

SUB2
ATP-dependent RNA helicase SUB2

1

4

High-throughput

0.479

High

419537

SUS1
SAGA complex subunit SUS1

1

1

Small-scale

0.479

High

419338

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.458

High

419472

DCP2
m7GpppN-mRNA hydrolase

1

0

Small-scale

0.458

High

419510

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

419511

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

419513

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

419522

THP1
Nuclear mRNA export protein THP1

1

0

Small-scale

0.458

High

419538

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.458

High

419344

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

Small-scale

0.457

High

419449

IOC3
ISWI one complex protein 3

1

1

Small-scale

0.457

High

419526

ENV7
Serine/threonine-protein kinase ENV7

1

1

Small-scale

0.457

High

419331

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

419332

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

419333

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

419389

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

419432

EAF5
Chromatin modification-related protein EAF5

1

1

Small-scale

0.445

High

419435

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

419456

EAF6
Chromatin modification-related protein EAF6

1

1

Small-scale

0.445

High

419514

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.445

High

149461

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.437

High

383392

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

409812

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

419313

RL26A
Large ribosomal subunit protein uL24A

1

7

High-throughput

0.437

High

419315

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

419317

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

419321

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

419324

MYO1
Myosin-1

1

2

Small-scale

0.437

High

419326

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

419328

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

419329

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

419339

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

419340

DPOLA
DNA polymerase alpha catalytic subunit A

1

1

Small-scale

0.437

High

419351

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.437

High

419366

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.437

High

419367

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.437

High

419368

KRR1
KRR1 small subunit processome component

1

6

High-throughput

0.437

High

419369

CSM1
Monopolin complex subunit CSM1

1

1

Small-scale

0.437

High

419370

SPB4
ATP-dependent rRNA helicase SPB4

1

9

High-throughput

0.437

High

419373

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

419385

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

1

High-throughput

0.437

High

419387

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

419396

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

419405

EBP2
rRNA-processing protein EBP2

1

3

High-throughput

0.437

High

419420

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

419424

DMA1
E3 ubiquitin-protein ligase DMA1

1

1

Small-scale

0.437

High

419438

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.437

High

419440

NTA1
Protein N-terminal amidase

1

1

High-throughput

0.437

High

419441

MLP2
Protein MLP2

1

14

High-throughput

0.437

High

419442

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

419443

FKS2
1,3-beta-glucan synthase component GSC2

1

1

High-throughput

0.437

High

419450

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.437

High

419452

CTK3
CTD kinase subunit gamma

1

1

Small-scale

0.437

High

419458

SEC16
COPII coat assembly protein SEC16

1

1

High-throughput

0.437

High

419460

ASE1
Anaphase spindle elongation protein

1

17

High-throughput

0.437

High

419475

GIS2
Zinc finger protein GIS2

1

4

High-throughput

0.437

High

419478

DMA2
E3 ubiquitin-protein ligase DMA2

1

1

Small-scale

0.437

High

419487

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

419490

GIP3
GLC7-interacting protein 3

1

1

High-throughput

0.437

High

419498

DHR1
Probable ATP-dependent RNA helicase DHR1

1

10

High-throughput

0.437

High

419501

UTP14
U3 small nucleolar RNA-associated protein 14

1

3

High-throughput

0.437

High

419503

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.437

High

419534

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.437

High

419535

GLT1
Glutamate synthase [NADH]

1

2

High-throughput

0.437

High

419336

MCM1
Pheromone receptor transcription factor

1

0

High-throughput

0.426

High

419360

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

419327

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.407

High

419343

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.407

High

419395

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

419404

LHS1
Heat shock protein 70 homolog LHS1

1

10

High-throughput

0.407

High

419427

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.407

High

419431

HSP7E
Heat shock protein SSC3, mitochondrial

1

10

High-throughput

0.407

High

419446

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.407

High

419466

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.407

High

408538

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

419325

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

419402

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

419415

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

419429

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

419459

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

419469

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.249

Low

419470

CENPQ
Inner kinetochore subunit OKP1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025