HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: UGGG2 (Q9NYU1)
UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)
Gene: UGGT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33957083, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment GO:0032991 - protein-containing complex GO:0036503 - ERAD pathway and 1 others more... GO:0051082 - unfolded protein binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 1516
+	Hs
		504869 HSP7C_HUMAN (26-637): 0: 916: 66.02		UGGG1_HUMAN (25-1515): 0: 1928: 54.98
+	Hs
		502617 BIP_HUMAN (19-654): 0: 914: 100.00		UGGG1_HUMAN (25-1515): 0: 1928: 54.98
+	Hs
		502321 BIP_HUMAN (19-654): 0: 914: 100.00		LARG2_HUMAN (1229-1447): 6.42e-54: 204: 17.62
+	Hs
		49265 HSP7C_HUMAN (26-637): 0: 916: 66.02		GXLT2_HUMAN (1231-1463): 3.46e-49: 183: 19.05
+	Hs
		502545 BIP_HUMAN (19-654): 0: 914: 100.00		GL8D2_HUMAN (1234-1477): 1.21e-16: 85.3: 15.19