HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: NFKB1 (P19838)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25609649
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0034774 - secretory granule lumen
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 968
+	Hs
		587444 HS71L_HUMAN (2-646): 0: 966: 82.48		NFKB1_HUMAN (1-968): 0: 796: 100.00
+	Hs
		503913 HSP7C_HUMAN (1-646): 0: 967: 100.00		RELB_HUMAN (30-459): 1.19e-121: 384: 33.10
+	Hs
		713946 HS71L_HUMAN (2-646): 0: 966: 82.48		RELB_HUMAN (30-459): 1.19e-121: 384: 33.10
+	Hs
		503938 HSP7C_HUMAN (1-646): 0: 967: 100.00		TF65_HUMAN (28-420): 6.77e-116: 368: 34.41
+	Hs
		713948 HS71L_HUMAN (2-646): 0: 966: 82.48		TF65_HUMAN (28-420): 6.77e-116: 368: 34.41
+	Hs
		503943 HSP7C_HUMAN (1-646): 0: 967: 100.00		REL_HUMAN (35-484): 6.21e-110: 354: 33.91
+	Hs
		713949 HS71L_HUMAN (2-646): 0: 966: 82.48		REL_HUMAN (35-484): 6.21e-110: 354: 33.91
+	Hs
		503916 HSP7C_HUMAN (1-646): 0: 967: 100.00		ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37
+	Hs
		503471 HSP7C_HUMAN (1-646): 0: 967: 100.00		IKBA_HUMAN (485-767): 1.18e-66: 228: 35.45
+	Hs
		503777 HSP7C_HUMAN (1-646): 0: 967: 100.00		RIPK4_HUMAN (478-862): 1.18e-61: 227: 21.00
+	Hs
		639682 HS71L_HUMAN (2-646): 0: 966: 82.48		IKBA_HUMAN (485-767): 1.18e-66: 228: 35.45
+	Mm
		926175 HSP7C_MOUSE (1-646): 0: 967: 99.85		IKBA_MOUSE (541-767): 9.47e-33: 131: 40.00
+	Hs
		121564 HSP7C_HUMAN (1-646): 0: 967: 100.00		IKBE_HUMAN (541-751): 2.35e-29: 125: 38.07
+	Hs
		121572 HS71L_HUMAN (2-646): 0: 966: 82.48		IKBE_HUMAN (541-751): 2.35e-29: 125: 38.07
+	Hs
		503906 HSP7C_HUMAN (1-646): 0: 967: 100.00		NFKB2_HUMAN (701-942): 4.27e-26: 117: 14.23
+	Hs
		713945 HS71L_HUMAN (2-646): 0: 966: 82.48		NFKB2_HUMAN (701-942): 4.27e-26: 117: 14.23
+	Hs
		504130 HSP7C_HUMAN (1-646): 0: 967: 100.00		IKBB_HUMAN (541-743): 4.59e-20: 95.1: 32.39
+	Hs
		713979 HS71L_HUMAN (2-646): 0: 966: 82.48		IKBB_HUMAN (541-743): 4.59e-20: 95.1: 32.39
+	Hs
		504758 HSP7C_HUMAN (1-646): 0: 967: 100.00		Q9H4D1_HUMAN (622-789): 9.95e-18: 90.6: 24.41
+	Hs
		504362 HSP7C_HUMAN (1-646): 0: 967: 100.00		ANKH1_HUMAN (797-964): 4.27e-16: 85.7: 12.64