HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: TNR1B (P20333)
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
Gene: TNFRSF1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0016020 - membrane GO:0031625 - ubiquitin protein ligase binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 461
+	Hs
		591270 HS71L_HUMAN (2-646): 0: 966: 82.48		TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00
+	Hs
		564001 HSP76_HUMAN (6-646): 0: 955: 77.54		TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00
+	Hs
		503470 HSP7C_HUMAN (1-646): 0: 967: 100.00		TNR5_HUMAN (29-267): 7.76e-40: 146: 26.12
+	Hs
		503413 HSP7C_HUMAN (1-646): 0: 967: 100.00		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		584330 HS71L_HUMAN (2-646): 0: 966: 82.48		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		563998 HSP76_HUMAN (6-646): 0: 955: 77.54		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		502805 HSP7C_HUMAN (1-646): 0: 967: 100.00		LAMC1_HUMAN (31-256): 1.09e-10: 66.1: 12.77