HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: CD11B (P21127)
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
Gene: CDK11B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15344906
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051726 - regulation of cell cycle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 795
+	Hs
		503460 HSP7C_HUMAN (1-646): 0: 967: 100.00		CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96
+	Hs
		503902 HSP7C_HUMAN (1-646): 0: 967: 100.00		CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64
+	Hs
		713942 HS71L_HUMAN (2-646): 0: 966: 82.48		CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64
+	Hs
		504111 HSP7C_HUMAN (1-646): 0: 967: 100.00		CDK10_HUMAN (429-760): 3.17e-133: 401: 52.41
+	At
		612295 HS701_ARATH (3-646): 0: 944: 76.35		CDKA1_ARATH (435-726): 1.55e-138: 412: 45.09
+	Mm
		509463 HSP72_MOUSE (2-612): 0: 936: 87.77		CDK1_MOUSE (435-726): 4.35e-136: 406: 42.18
+	Hs
		503702 HSP7C_HUMAN (1-646): 0: 967: 100.00		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69
+	Hs
		564038 HSP76_HUMAN (6-646): 0: 955: 77.54		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69
+	Hs
		483754 HS71A_HUMAN (1-646): 0: 948: 84.37		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69