HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.637

Property	Details
Experiments	24189400, 31980649, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, ubiquitin reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1342
+	Hs
		383840 Q53FC7_HUMAN (6-646): 0: 951: 77.07		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337839 HSP7C_HUMAN (1-646): 0: 967: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338019 HS71L_HUMAN (2-646): 0: 966: 82.48		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338516 Q53GZ6_HUMAN (1-646): 0: 966: 99.85		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338520 Q59EJ3_HUMAN (1-646): 0: 958: 84.06		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338514 Q53FC7_HUMAN (6-646): 0: 951: 77.07		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337827 HS71A_HUMAN (1-646): 0: 948: 84.37		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338182 HSP72_HUMAN (2-646): 0: 940: 85.47		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337324 HSP7C_HUMAN (1-646): 0: 967: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		435511 HSP7C_HUMAN (1-646): 0: 967: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		503499 HSP7C_HUMAN (1-646): 0: 967: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Gg
		94427 HSP70_CHICK (3-646): 0: 981: 85.91		KSYK_CHICK (715-958): 2e-43: 170: 36.80
+	Hs
		503608 HSP7C_HUMAN (1-646): 0: 967: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Gg
		94419 HSP7C_CHICK (1-646): 0: 960: 97.99		KSYK_CHICK (715-958): 2e-43: 170: 36.80
+	Hs
		789047 HSP72_HUMAN (2-646): 0: 940: 85.47		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Rn
		544811 HSP7C_RAT (1-646): 0: 967: 99.85		INSR_RAT (329-650): 1.42e-20: 101: 16.71