Protein: RL5
Large ribosomal subunit protein uL5 (50S ribosomal protein L5)

Gene: RL5, rplE
Organism: Escherichia coli K-12
Interactions: 87
UniProt ID: P62399

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000049 - tRNA binding
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

421131

PNP
Polyribonucleotide nucleotidyltransferase

2

1

High-throughput

0.588

High

497362

MREB
Cell shape-determining protein MreB

2

3

High-throughput

0.588

High

953319

RL4
Large ribosomal subunit protein uL4

2

1

High-throughput

0.588

High

499958

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.576

High

491561

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

2

0

High-throughput

0.563

High

975608

YAJL
Protein/nucleic acid deglycase 3

2

0

Small-scale

0.547

High

491330

HSCA
Chaperone protein HscA

1

2

High-throughput

0.536

High

492880

RL27
Large ribosomal subunit protein bL27

1

1

High-throughput

0.536

High

840173

OBG
GTPase ObgE/CgtA

1

1

High-throughput

0.536

High

786973

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

0

High-throughput

0.517

High

365843

RPOD
RNA polymerase sigma factor RpoD

1

0

High-throughput

0.513

High

382596

RS6
Small ribosomal subunit protein bS6

1

0

High-throughput

0.513

High

408533

3MG2
DNA-3-methyladenine glycosylase 2

1

0

High-throughput

0.513

High

469932

RECB
RecBCD enzyme subunit RecB

1

0

High-throughput

0.513

High

480644

RHAS
HTH-type transcriptional activator RhaS

1

0

High-throughput

0.513

High

491772

MINE
Cell division topological specificity factor

1

0

High-throughput

0.513

High

496825

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

0

High-throughput

0.513

High

498095

YCED
Large ribosomal RNA subunit accumulation protein YceD

1

0

High-throughput

0.513

High

498903

GLRX4
Glutaredoxin 4

1

0

High-throughput

0.513

High

500714

NUSA
Transcription termination/antitermination protein NusA

1

0

High-throughput

0.513

High

501041

SSPB
Stringent starvation protein B

1

0

High-throughput

0.513

High

559592

FDHE
Protein FdhE

1

0

High-throughput

0.513

High

613292

MINC
Septum site-determining protein MinC

1

0

High-throughput

0.513

High

749445

PSUG
Pseudouridine-5'-phosphate glycosidase

1

0

High-throughput

0.513

High

975598

PTQA
PTS system N,N'-diacetylchitobiose-specific EIIA component

1

0

High-throughput

0.513

High

975599

PTFAH
Multiphosphoryl transfer protein

1

0

High-throughput

0.513

High

490942

IHFA
Integration host factor subunit alpha

1

1

High-throughput

0.484

High

490974

IHFB
Integration host factor subunit beta

1

1

High-throughput

0.484

High

497441

CSPC
Cold shock-like protein CspC

1

2

High-throughput

0.484

High

497650

RLUC
Ribosomal large subunit pseudouridine synthase C

1

1

High-throughput

0.484

High

498403

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

2

High-throughput

0.484

High

515983

RCSB
Transcriptional regulatory protein RcsB

1

1

High-throughput

0.484

High

785879

CBPA
Curved DNA-binding protein

1

1

High-throughput

0.484

High

788378

RLMN
Dual-specificity RNA methyltransferase RlmN

1

1

High-throughput

0.484

High

790850

RLUB
Ribosomal large subunit pseudouridine synthase B

1

1

High-throughput

0.484

High

498316

PCNB
Poly(A) polymerase I

1

0

High-throughput

0.479

High

497120

DEAD
ATP-dependent RNA helicase DeaD

1

3

High-throughput

0.479

High

490275

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

490686

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

490833

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.464

High

491515

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.464

High

491956

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.464

High

492257

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

494649

RPOA
DNA-directed RNA polymerase subunit alpha

1

0

High-throughput

0.464

High

496448

FTSZ
Cell division protein FtsZ

1

0

High-throughput

0.464

High

496637

LDCI
Inducible lysine decarboxylase

1

0

High-throughput

0.464

High

496740

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

500493

SKP
Chaperone protein Skp

1

0

High-throughput

0.464

High

500737

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.464

High

491871

NAGB
Glucosamine-6-phosphate deaminase

1

0

High-throughput

0.458

High

495591

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

496000

DARP
Dual-action ribosomal maturation protein DarP

1

0

High-throughput

0.458

High

496883

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

501655

YHBY
RNA-binding protein YhbY

1

0

High-throughput

0.458

High

663240

PHOP
Transcriptional regulatory protein PhoP

1

0

High-throughput

0.458

High

975600

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

716089

LHR
Lhr helicase/uracil glycosylase

1

1

High-throughput

0.437

High

491688

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.426

High

494994

TIG
Trigger factor

1

0

Small-scale

0.426

High

495452

TRMB
tRNA

2

0

High-throughput

0.307

High

975601

YBJX
Uncharacterized protein YbjX

2

0

High-throughput

0.307

High

444253

BTUE
Thioredoxin/glutathione peroxidase BtuE

1

0

High-throughput

0.279

Low

498131

YCGL
Protein YcgL

1

0

High-throughput

0.279

Low

498244

ATPB
ATP synthase subunit beta

1

0

High-throughput

0.279

Low

498894

NRDH
Glutaredoxin-like protein NrdH

1

0

High-throughput

0.279

Low

499475

FUMD
Fumarase D

1

0

High-throughput

0.279

Low

659118

FECI
Ferric citrate uptake sigma factor FecI

1

0

High-throughput

0.279

Low

744428

YJBM
Uncharacterized protein YjbM

1

0

High-throughput

0.279

Low

788483

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

788844

FXSA
UPF0716 protein FxsA

1

0

High-throughput

0.279

Low

791932

USPF
Universal stress protein F

1

0

High-throughput

0.279

Low

975596

YDIZ
Uncharacterized protein YdiZ

1

0

High-throughput

0.279

Low

975597

YHCO
Uncharacterized protein YhcO

1

0

High-throughput

0.279

Low

975602

YMGA
Probable two-component-system connector protein YmgA

1

0

High-throughput

0.279

Low

975603

YCGY
Uncharacterized protein YcgY

1

0

High-throughput

0.279

Low

975605

DMLR
HTH-type transcriptional regulator DmlR

1

0

High-throughput

0.279

Low

975606

YFDK
Uncharacterized protein YfdK

1

0

High-throughput

0.279

Low

975607

RPNB
Recombination-promoting nuclease RpnB

1

0

High-throughput

0.279

Low

499462

LAPA
Lipopolysaccharide assembly protein A

1

0

High-throughput

0.261

Low

498913

KDTA
3-deoxy-D-manno-octulosonic acid transferase

1

0

High-throughput

0.253

Low

516003

RCSA
Transcriptional regulatory protein RcsA

1

0

High-throughput

0.253

Low

578600

SRLR
Glucitol operon repressor

1

0

High-throughput

0.253

Low

676594

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

1

0

High-throughput

0.253

Low

393907

PBPA
Penicillin-binding protein 1A

1

0

High-throughput

0.249

Low

499633

NLPD
Murein hydrolase activator NlpD

1

0

High-throughput

0.249

Low

790831

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

975604

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025