HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	27684187, 32687490, 15324660, 21827211
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016020 - membrane GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 245
+	Hs
		503828 HSP7C_HUMAN (1-646): 0: 967: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Mm
		910222 HSP7C_MOUSE (1-646): 0: 967: 99.85		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		503857 HSP7C_HUMAN (1-646): 0: 967: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		713939 HS71L_HUMAN (2-646): 0: 966: 82.48		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		503532 HSP7C_HUMAN (1-646): 0: 967: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	At
		788425 HS704_ARATH (3-646): 0: 948: 76.35		14331_ARATH (3-242): 2.67e-142: 400: 61.07
+	At
		612300 HS701_ARATH (3-646): 0: 944: 76.35		14333_ARATH (3-243): 8e-143: 401: 61.63
+	At
		612299 HS701_ARATH (3-646): 0: 944: 76.35		14331_ARATH (3-242): 2.67e-142: 400: 61.07
+	Mm
		565423 HSP72_MOUSE (2-612): 0: 936: 87.77		1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00
+	At
		612330 HS702_ARATH (3-646): 0: 929: 75.77		14332_ARATH (3-243): 8.65e-144: 404: 61.22
+	At
		250053 HSP7C_ARATH (3-646): 0: 931: 74.81		14331_ARATH (3-242): 2.67e-142: 400: 61.07
+	Hs
		503533 HSP7C_HUMAN (1-646): 0: 967: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		503945 HSP7C_HUMAN (1-646): 0: 967: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		503818 HSP7C_HUMAN (1-646): 0: 967: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33