Protein: RS28
Small ribosomal subunit protein eS28 (40S ribosomal protein S28)

Gene: RS28, RPS28
Organism: Homo sapiens
Interactions: 238
UniProt ID: P62857

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

983114

RS26
Small ribosomal subunit protein eS26

6

4

High-throughput

0.931

High

860474

RS5
Small ribosomal subunit protein uS7

4

2

High-throughput

0.881

High

187691

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

0

High-throughput

0.716

High

983312

SERB1
SERPINE1 mRNA-binding protein 1

5

0

High-throughput

0.672

High

969769

RS16
Small ribosomal subunit protein uS9

3

2

High-throughput

0.656

High

446867

NPM
Nucleophosmin

3

0

High-throughput

0.638

High

591583

H2AX
Histone H2AX

2

1

High-throughput

0.628

High

687198

HMGB2
High mobility group protein B2

2

1

Small-scale

0.625

High

983279

CUL3
Cullin-3

2

2

High-throughput

0.611

High

983269

KRA11
Keratin-associated protein 1-1

2

5

High-throughput

0.606

High

983265

RL19
Large ribosomal subunit protein eL19

2

0

High-throughput

0.602

High

983286

RRS1
Ribosome biogenesis regulatory protein homolog

2

0

High-throughput

0.602

High

983280

BYST
Bystin

2

1

High-throughput

0.601

High

983282

RBM39
RNA-binding protein 39

2

0

High-throughput

0.585

High

371685

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

862003

YAP1
Transcriptional coactivator YAP1

2

2

High-throughput

0.584

High

983291

LARP7
La-related protein 7

2

1

High-throughput

0.584

High

269172

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

830509

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

505312

KRA23
Keratin-associated protein 2-3

1

5

High-throughput

0.573

High

950228

KR107
Keratin-associated protein 10-7

1

4

High-throughput

0.573

High

950450

KR108
Keratin-associated protein 10-8

1

5

High-throughput

0.573

High

395847

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

983339

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

332498

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.549

High

983303

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

619704

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

687958

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

941390

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.541

High

983334

KR412
Keratin-associated protein 4-12

1

5

High-throughput

0.541

High

161804

RIOK3
Serine/threonine-protein kinase RIO3

1

5

High-throughput

0.536

High

180771

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.536

High

240143

FGF17
Fibroblast growth factor 17

1

1

High-throughput

0.536

High

431076

LA
Lupus La protein

1

1

High-throughput

0.536

High

481209

HMGB1
High mobility group protein B1

1

1

High-throughput

0.536

High

502299

H2A1
Histone H2A type 1

1

1

High-throughput

0.536

High

625298

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

658092

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.536

High

832004

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.536

High

939291

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.536

High

959713

RS3A
Small ribosomal subunit protein eS1

1

4

High-throughput

0.536

High

969156

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

973378

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

983255

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

983260

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

983261

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.536

High

983276

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.536

High

983278

CUL1
Cullin-1

1

2

High-throughput

0.536

High

983290

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.536

High

983323

FGF13
Fibroblast growth factor 13

1

1

High-throughput

0.536

High

983324

CUL5
Cullin-5

1

2

High-throughput

0.536

High

983333

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.536

High

983338

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

983348

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.536

High

983362

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.536

High

529551

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.528

High

271488

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

303504

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

479388

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

542436

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

581499

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

High-throughput

0.513

High

595382

H15
Histone H1.5

1

0

High-throughput

0.513

High

785071

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

842310

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

859206

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

884047

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

886418

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

896989

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

933298

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

951077

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

983256

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

983259

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.513

High

983272

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.513

High

983281

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

983283

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

983288

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

0

High-throughput

0.513

High

983307

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

983309

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.513

High

983316

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

983337

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.513

High

983342

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.513

High

983346

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

983356

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

983363

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

983365

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

983327

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.493

High

261787

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.486

High

211300

RFOX2
RNA binding protein fox-1 homolog 2

1

1

High-throughput

0.481

High

949848

KR103
Keratin-associated protein 10-3

1

5

High-throughput

0.481

High

983344

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

1

High-throughput

0.481

High

285191

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

315413

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

323294

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

330842

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

406012

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

427861

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.479

High

476635

RSSA
Small ribosomal subunit protein uS2

1

4

High-throughput

0.479

High

606578

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

667737

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

684177

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

858615

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

High-throughput

0.479

High

940903

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

983268

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

983274

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

983275

ERCC8
DNA excision repair protein ERCC-8

1

1

Small-scale

0.479

High

983284

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

983294

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

983295

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

983297

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

983299

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

983306

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.479

High

983315

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

983321

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

983322

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

983330

THOC3
THO complex subunit 3

1

1

Small-scale

0.479

High

983345

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

983354

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

983361

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

983367

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

983326

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.460

High

65526

DDTL
D-dopachrome decarboxylase-like protein

1

0

High-throughput

0.458

High

125392

LEG9
Galectin-9

1

0

High-throughput

0.458

High

128942

MEN1
Menin

1

0

High-throughput

0.458

High

131917

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

134659

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

157203

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

158171

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

194110

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

222915

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

254587

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.458

High

276769

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

277915

SH3L1
Adapter SH3BGRL

1

0

Small-scale

0.458

High

293520

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

324744

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

332099

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.458

High

335077

ARI2
E3 ubiquitin-protein ligase ARIH2

1

0

High-throughput

0.458

High

360183

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.458

High

375368

RASK
GTPase KRas

1

0

High-throughput

0.458

High

387400

APOE
Apolipoprotein E

1

0

High-throughput

0.458

High

389249

FINC
Fibronectin

1

0

High-throughput

0.458

High

402761

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

464141

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.458

High

472604

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

534900

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

550965

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

565316

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

583264

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

599573

STMN1
Stathmin

1

0

High-throughput

0.458

High

623252

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

715525

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

720104

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

748990

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.458

High

764629

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

766414

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

783224

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.458

High

786511

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

828640

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.458

High

867007

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

876810

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

878918

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

887930

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

912544

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.458

High

946398

MTPN
Myotrophin

1

0

High-throughput

0.458

High

947136

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

948762

CD81
CD81 antigen

1

0

High-throughput

0.458

High

970267

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

979454

H4
Histone H4

1

0

High-throughput

0.458

High

981777

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

983254

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

983257

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

983262

H31
Histone H3.1

1

0

High-throughput

0.458

High

983263

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.458

High

983264

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

983266

LRP2
Low-density lipoprotein receptor-related protein 2

1

0

High-throughput

0.458

High

983267

CYC
Cytochrome c

1

0

High-throughput

0.458

High

983270

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

983271

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.458

High

983273

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

983285

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

983287

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

983289

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

983292

MIDN
Midnolin

1

0

High-throughput

0.458

High

983293

CEP78
Centrosomal protein of 78 kDa

1

0

High-throughput

0.458

High

983298

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

983302

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

983305

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

983308

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

983310

DOCK4
Dedicator of cytokinesis protein 4

1

0

High-throughput

0.458

High

983314

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

983317

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

983318

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

983319

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

983320

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

983325

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.458

High

983328

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

983329

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

983331

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

983335

MEP50
Methylosome protein WDR77

1

0

High-throughput

0.458

High

983340

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

983341

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

983343

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

983347

ANLN
Anillin

1

0

High-throughput

0.458

High

983350

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

983353

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

983355

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

983357

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

983358

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.458

High

983360

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.458

High

429677

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

626161

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

765344

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

934416

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

983277

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

983296

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

1

Small-scale

0.445

High

983336

RIOK1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.445

High

983359

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

983366

MAFB
Transcription factor MafB

1

1

High-throughput

0.437

High

344159

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

354649

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

516498

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

563572

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

983258

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

983349

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.426

High

886722

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

983351

GIN1
Gypsy retrotransposon integrase-like protein 1

2

0

High-throughput

0.305

High

983313

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

983332

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.251

Low

318707

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

377512

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

983304

WDR53
WD repeat-containing protein 53

1

0

High-throughput

0.249

Low

983311

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

983352

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

983364

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1003

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

87415

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

254933

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

983300

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.232

Low

983301

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025