Protein: S61A1
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)

Gene: S61A1, SEC61A1
Organism: Homo sapiens
Interactions: 201
UniProt ID: P61619

Gene Ontology (top 5):
GO:0005048 - signal sequence binding
GO:0005262 - calcium channel activity
GO:0005784 - Sec61 translocon complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006613 - cotranslational protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890057

SC61B
Protein transport protein Sec61 subunit beta

7

6

Small-scale

0.956

High

528883

CFTR
Cystic fibrosis transmembrane conductance regulator

4

2

High-throughput

0.691

High

338228

EGFR
Epidermal growth factor receptor

4

4

Small-scale

0.686

High

654230

CALX
Calnexin

4

1

Small-scale

0.683

High

901544

SEC63
Translocation protein SEC63 homolog

1

5

High-throughput

0.665

High

790325

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.656

High

888016

SC61G
Protein transport protein Sec61 subunit gamma

1

2

Small-scale

0.647

High

501910

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.611

High

901463

ILK
Integrin-linked protein kinase

2

0

High-throughput

0.602

High

383723

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

4

High-throughput

0.584

High

901504

RN149
E3 ubiquitin-protein ligase RNF149

2

2

Small-scale

0.584

High

548673

VAV
Proto-oncogene vav

3

1

High-throughput

0.578

High

373987

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

1

High-throughput

0.569

High

322414

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

901523

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

879794

TPTE
Putative tyrosine-protein phosphatase TPTE

1

3

High-throughput

0.554

High

384593

NTRK1
High affinity nerve growth factor receptor

2

8

High-throughput

0.543

High

283455

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

435593

IGF1R
Insulin-like growth factor 1 receptor

1

8

High-throughput

0.536

High

901449

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

901492

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.536

High

901496

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

901513

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

901531

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

227050

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.533

High

573649

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

2

High-throughput

0.533

High

901473

TNIP1
TNFAIP3-interacting protein 1

2

3

High-throughput

0.533

High

901493

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

0

Small-scale

0.517

High

301373

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

High-throughput

0.515

High

418106

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

430121

PROF1
Profilin-1

1

0

High-throughput

0.513

High

447895

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

736348

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

805910

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

813309

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

828697

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

884694

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

901447

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

901452

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.513

High

901454

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

901468

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

901536

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

210895

GET3
ATPase GET3

1

1

Small-scale

0.501

High

411348

INSR
Insulin receptor

1

9

High-throughput

0.500

High

452383

PGFRB
Platelet-derived growth factor receptor beta

1

7

High-throughput

0.500

High

901460

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

7

High-throughput

0.500

High

364230

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

901446

AP1S1
AP-1 complex subunit sigma-1A

1

0

High-throughput

0.493

High

714650

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.489

High

729255

VGFR3
Vascular endothelial growth factor receptor 3

1

4

High-throughput

0.489

High

901476

NTRK3
NT-3 growth factor receptor

1

8

High-throughput

0.489

High

901479

DDR2
Discoidin domain-containing receptor 2

1

7

High-throughput

0.489

High

901487

STYK1
Tyrosine-protein kinase STYK1

1

1

High-throughput

0.489

High

901508

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

1

High-throughput

0.489

High

901511

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

6

High-throughput

0.489

High

901521

RBM42
RNA-binding protein 42

1

1

High-throughput

0.489

High

901546

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.489

High

776284

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.486

High

803473

BAG6
Large proline-rich protein BAG6

1

0

Small-scale

0.480

High

279501

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

376446

APOB
Apolipoprotein B-100

1

2

Small-scale

0.479

High

441474

MET
Hepatocyte growth factor receptor

1

6

High-throughput

0.479

High

445840

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

7

High-throughput

0.479

High

475559

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

561543

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.479

High

584360

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.479

High

591294

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

821964

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

847428

BAP31
B-cell receptor-associated protein 31

1

3

Small-scale

0.479

High

866921

MOT1
Monocarboxylate transporter 1

1

3

High-throughput

0.479

High

873121

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

3

High-throughput

0.479

High

901450

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

901458

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.479

High

901462

CLN3
Battenin

1

1

Small-scale

0.479

High

901466

CUL3
Cullin-3

1

1

High-throughput

0.479

High

901484

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.479

High

901495

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

Small-scale

0.479

High

901497

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

901506

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

901518

DERL3
Derlin-3

1

3

Small-scale

0.479

High

901520

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

901522

DERL1
Derlin-1

1

3

Small-scale

0.479

High

901526

DERL2
Derlin-2

1

3

Small-scale

0.479

High

901534

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

901538

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

901549

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.479

High

849976

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.470

High

267229

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

350023

RASK
GTPase KRas

1

0

High-throughput

0.458

High

382375

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

Small-scale

0.458

High

429001

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

456841

FURIN
Furin

1

0

High-throughput

0.458

High

503812

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

648706

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

726131

BASI
Basigin

1

0

High-throughput

0.458

High

750205

COIL
Coilin

1

0

High-throughput

0.458

High

898568

RL26
Large ribosomal subunit protein uL24

1

0

Small-scale

0.458

High

901485

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

901488

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

901490

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

901515

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

901542

NCDN
Neurochondrin

1

0

High-throughput

0.458

High

901545

TMCO1
Calcium load-activated calcium channel

1

0

Small-scale

0.458

High

890564

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.457

High

901459

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

8

High-throughput

0.457

High

265509

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

Small-scale

0.445

High

155323

NRP1
Neuropilin-1

1

1

High-throughput

0.437

High

177859

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

260542

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.437

High

546835

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.437

High

572613

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.437

High

587495

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.437

High

609236

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.437

High

671775

PDIA3
Protein disulfide-isomerase A3

1

1

Small-scale

0.437

High

674378

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.437

High

738189

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.437

High

781018

OPRD
Delta-type opioid receptor

1

1

Small-scale

0.437

High

901456

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

High-throughput

0.437

High

901457

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

901472

CUL7
Cullin-7

1

1

High-throughput

0.437

High

901475

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

901480

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

4

High-throughput

0.437

High

901481

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

901489

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

901494

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

901500

TM192
Transmembrane protein 192

1

1

High-throughput

0.437

High

901530

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

901540

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.437

High

901541

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.437

High

901547

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.437

High

901550

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.437

High

795093

SSRA
Translocon-associated protein subunit alpha

1

0

Small-scale

0.426

High

901502

S15A4
Solute carrier family 15 member 4

1

0

Small-scale

0.426

High

901528

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.426

High

92783

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

397881

ISG15
Ubiquitin-like protein ISG15

1

3

Small-scale

0.407

High

901514

Q96D37
VAV1 protein

1

1

High-throughput

0.407

High

205238

TGON2
Trans-Golgi network integral membrane protein 2

3

0

High-throughput

0.330

High

901543

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.305

High

346399

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

901451

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.279

Low

901469

RBM39
RNA-binding protein 39

1

0

High-throughput

0.279

Low

901510

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.279

Low

901524

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.279

Low

901533

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.279

Low

146616

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.269

Low

637234

CATS
Cathepsin S

1

0

High-throughput

0.269

Low

779148

CCNF
Cyclin-F

1

0

High-throughput

0.269

Low

901519

NECD
Necdin

1

0

High-throughput

0.269

Low

352552

TNFA
Tumor necrosis factor

1

0

Small-scale

0.261

Low

901525

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

122610

MEN1
Menin

1

0

High-throughput

0.249

Low

320191

ERR2
Steroid hormone receptor ERR2

1

0

High-throughput

0.249

Low

386430

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

544953

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

552406

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

577868

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.249

Low

650853

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720137

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

807670

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

823798

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

830867

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

841125

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.249

Low

858221

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.249

Low

868110

ATX3
Ataxin-3

1

0

High-throughput

0.249

Low

901448

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

901453

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

901455

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

901461

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

901464

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

901465

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

Small-scale

0.249

Low

901467

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

901470

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.249

Low

901474

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.249

Low

901477

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

901478

DUS7
Dual specificity protein phosphatase 7

1

0

High-throughput

0.249

Low

901482

KCD21
BTB/POZ domain-containing protein KCTD21

1

0

Small-scale

0.249

Low

901483

MIDN
Midnolin

1

0

High-throughput

0.249

Low

901486

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

901491

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

901498

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low

901499

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

901503

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.249

Low

901505

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

901507

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

901509

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.249

Low

901512

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

901516

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

901517

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

901527

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

901532

WDR76
WD repeat-containing protein 76

1

0

High-throughput

0.249

Low

901535

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

901537

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

901539

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

901548

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.249

Low

1001

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

135236

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low

230596

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

901471

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low

901501

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

901529

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024