HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 448
+	Hs
		564067 HSP76_HUMAN (6-646): 0: 955: 77.54		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Hs
		503528 HSP7C_HUMAN (1-646): 0: 967: 100.00		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		160349 HSP7C_HUMAN (1-646): 0: 967: 100.00		AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12
+	Hs
		564016 HSP76_HUMAN (6-646): 0: 955: 77.54		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		160460 HSP72_HUMAN (2-646): 0: 940: 85.47		AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12
+	Hs
		503996 HSP7C_HUMAN (1-646): 0: 967: 100.00		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		713953 HS71L_HUMAN (2-646): 0: 966: 82.48		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		504007 HSP7C_HUMAN (1-646): 0: 967: 100.00		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		564065 HSP76_HUMAN (6-646): 0: 955: 77.54		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		503929 HSP7C_HUMAN (1-646): 0: 967: 100.00		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57
+	Hs
		564066 HSP76_HUMAN (6-646): 0: 955: 77.54		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		871550 HSP72_HUMAN (2-646): 0: 940: 85.47		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		871551 HSP72_HUMAN (2-646): 0: 940: 85.47		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		503561 HSP7C_HUMAN (1-646): 0: 967: 100.00		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		483778 HS71B_HUMAN (1-646): 0: 948: 84.37		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		734898 HSP72_HUMAN (2-646): 0: 940: 85.47		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		503636 HSP7C_HUMAN (1-646): 0: 967: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		564030 HSP76_HUMAN (6-646): 0: 955: 77.54		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09