HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	21951318, 21182203
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 530
+	Hs
		714036 HS71L_HUMAN (2-646): 0: 966: 82.48		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		564142 HSP76_HUMAN (6-646): 0: 955: 77.54		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368878 HSP7C_HUMAN (1-646): 0: 967: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369084 HS71L_HUMAN (2-646): 0: 966: 82.48		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368938 HSP76_HUMAN (6-646): 0: 955: 77.54		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369248 HSP72_HUMAN (2-646): 0: 940: 85.47		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		320162 HSP7C_HUMAN (1-646): 0: 967: 100.00		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		377052 HSP7C_HUMAN (1-646): 0: 967: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487886 HSP7C_HUMAN (1-646): 0: 967: 100.00		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		504003 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		503444 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Mm
		509285 HS71B_MOUSE (1-646): 0: 957: 83.90		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Gg
		430818 HSP70_CHICK (3-646): 0: 981: 85.91		PRGR_CHICK (149-408): 1.35e-39: 155: 33.58
+	Hs
		414425 HSP7C_HUMAN (1-646): 0: 967: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487079 HSP7C_HUMAN (1-646): 0: 967: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59