HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, unassigned2173, 14743216
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 947
+	Hs
		714054 HS71L_HUMAN (2-646): 0: 966: 82.48		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Mm
		926174 HSP7C_MOUSE (1-646): 0: 967: 99.85		M3K14_MOUSE (1-947): 0: 758: 83.98
+	Hs
		503528 HSP7C_HUMAN (1-646): 0: 967: 100.00		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		564016 HSP76_HUMAN (6-646): 0: 955: 77.54		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		504002 HSP7C_HUMAN (1-646): 0: 967: 100.00		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Rn
		871238 HSP7C_RAT (1-646): 0: 967: 99.85		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	Rn
		483815 HS71B_RAT (1-646): 0: 958: 84.06		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	Hs
		503719 HSP7C_HUMAN (1-646): 0: 967: 100.00		KS6A3_HUMAN (319-656): 2.54e-97: 324: 20.46
+	Hs
		503996 HSP7C_HUMAN (1-646): 0: 967: 100.00		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		713953 HS71L_HUMAN (2-646): 0: 966: 82.48		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		504119 HSP7C_HUMAN (1-646): 0: 967: 100.00		KS6A1_HUMAN (319-695): 1.9e-95: 318: 18.21
+	Hs
		564041 HSP76_HUMAN (6-646): 0: 955: 77.54		KS6A3_HUMAN (319-656): 2.54e-97: 324: 20.46
+	Hs
		564065 HSP76_HUMAN (6-646): 0: 955: 77.54		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		503599 HSP7C_HUMAN (1-646): 0: 967: 100.00		M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66
+	Hs
		713919 HS71L_HUMAN (2-646): 0: 966: 82.48		M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66
+	Hs
		504016 HSP7C_HUMAN (1-646): 0: 967: 100.00		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		713957 HS71L_HUMAN (2-646): 0: 966: 82.48		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		504640 HSP7C_HUMAN (1-646): 0: 967: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Hs
		714056 HS71L_HUMAN (2-646): 0: 966: 82.48		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Hs
		564068 HSP76_HUMAN (6-646): 0: 955: 77.54		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52