HitPredict

Interactor 1: KCNQ1 (P51787)
Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
Gene: KCNQ1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	26405101, 32173736, 23529131
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0044325 - transmembrane transporter binding GO:0060306 - regulation of membrane repolarization GO:0086005 - ventricular cardiac muscle cell action potential
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 676 Hs			1 975
+	Hs
		1058646 KCNB1_HUMAN (51-658): 1.72e-109: 352: 15.37		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		602911 KCNA3_HUMAN (80-440): 5.55e-91: 296: 19.35		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		808053 KCNQ1_HUMAN (1-676): 2.36e-175: 517: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Mm
		93274 SCN9A_MOUSE (14-637): 1.17e-20: 99.7: 9.33		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		69865 SCN2A_MOUSE (3-304): 2.04e-20: 98.9: 10.86		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		808358 SCN9A_MOUSE (14-637): 1.17e-20: 99.7: 9.33		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Mm
		69867 SCN2A_MOUSE (3-304): 2.04e-20: 98.9: 10.86		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Rn
		292480 KCNQ2_RAT (44-671): 2.68e-129: 404: 35.29		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82
+	Hs
		1079738 SCN9A_HUMAN (35-637): 5.74e-25: 113: 9.61		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Hs
		132322 CAC1A_HUMAN (5-398): 2.22e-25: 114: 11.54		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73