HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 32687490
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1235
+	Hs
		871777 HSP72_HUMAN (2-646): 0: 940: 85.47		SLK_HUMAN (1-1235): 0: 720: 100.00
+	Hs
		148327 HSP7C_HUMAN (1-646): 0: 967: 100.00		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		148449 HS71L_HUMAN (2-646): 0: 966: 82.48		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		148367 HSP76_HUMAN (6-646): 0: 955: 77.54		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		148576 HSP72_HUMAN (2-646): 0: 940: 85.47		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		871773 HSP72_HUMAN (2-646): 0: 940: 85.47		SIK2_HUMAN (21-837): 5.47e-122: 402: 16.01
+	Hs
		504037 HSP7C_HUMAN (1-646): 0: 967: 100.00		KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25
+	Hs
		504975 HSP7C_HUMAN (1-646): 0: 967: 100.00		KCC2A_HUMAN (31-423): 1.9e-113: 364: 25.25
+	Hs
		871553 HSP72_HUMAN (2-646): 0: 940: 85.47		PAK2_HUMAN (7-305): 1.42e-110: 358: 36.79
+	Hs
		503719 HSP7C_HUMAN (1-646): 0: 967: 100.00		KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49
+	Hs
		564041 HSP76_HUMAN (6-646): 0: 955: 77.54		KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49
+	Hs
		503996 HSP7C_HUMAN (1-646): 0: 967: 100.00		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	Hs
		713953 HS71L_HUMAN (2-646): 0: 966: 82.48		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	Hs
		564065 HSP76_HUMAN (6-646): 0: 955: 77.54		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	Hs
		871550 HSP72_HUMAN (2-646): 0: 940: 85.47		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	Ce
		450535 HSP1_CAEEL (1-646): 0: 937: 84.39		MIG15_CAEEL (29-390): 1.69e-55: 213: 33.07
+	Hs
		504029 HSP7C_HUMAN (1-646): 0: 967: 100.00		ROCK1_HUMAN (796-1223): 6.3e-17: 88.9: 11.01
+	Hs
		254440 HSP7C_HUMAN (1-646): 0: 967: 100.00		ROCK2_HUMAN (590-1232): 1.74e-15: 84.3: 10.38