Protein: SPSB3
SPRY domain-containing SOCS box protein 3 (SSB-3)

Gene: SPSB3
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q6PJ21

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0010719 - negative regulation of epithelial to mesenchymal transition
GO:0019005 - SCF ubiquitin ligase complex
GO:0031466 - Cul5-RING ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1245004

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

2

High-throughput

0.811

High

1245007

CUL5
Cullin-5

5

20

High-throughput

0.716

High

1119678

CDK13
Cyclin-dependent kinase 13

3

12

High-throughput

0.667

High

1245014

DOCK5
Dedicator of cytokinesis protein 5

2

13

High-throughput

0.628

High

1245017

KLK11
Kallikrein-11

3

3

High-throughput

0.609

High

1245010

ZN396
Zinc finger protein 396

2

2

High-throughput

0.606

High

1245016

RBX2
RING-box protein 2

2

12

High-throughput

0.601

High

1245020

NUMBL
Numb-like protein

3

9

High-throughput

0.597

High

1245001

PODN
Podocan

2

4

High-throughput

0.574

High

1245005

UXS1
UDP-glucuronic acid decarboxylase 1

2

5

High-throughput

0.574

High

1245006

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

12

High-throughput

0.574

High

563937

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.541

High

180315

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.536

High

288239

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

4

High-throughput

0.536

High

1125891

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

8

High-throughput

0.536

High

1158666

DPYL2
Dihydropyrimidinase-related protein 2

1

9

High-throughput

0.536

High

1245000

PLGT2
Protein O-glucosyltransferase 2

1

4

High-throughput

0.536

High

1245015

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

20

High-throughput

0.536

High

1103705

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

7

High-throughput

0.526

High

1177152

MICB
MHC class I polypeptide-related sequence B

1

3

High-throughput

0.514

High

467719

CEL2B
Chymotrypsin-like elastase family member 2B

1

2

High-throughput

0.489

High

596995

TSHR
Thyrotropin receptor

1

5

High-throughput

0.489

High

889295

NUMB
Protein numb homolog

1

6

High-throughput

0.489

High

1245018

GPN3
GPN-loop GTPase 3

1

2

High-throughput

0.489

High

1245019

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

7

High-throughput

0.489

High

995091

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.481

High

461606

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.479

High

468509

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

1147053

ELOC
Elongin-C

1

6

Small-scale

0.479

High

1147183

ELOB
Elongin-B

1

4

High-throughput

0.479

High

85172

B7Z5W0
cDNA FLJ53174, highly similar to Numb-like protein

1

9

High-throughput

0.470

High

705415

GRN
Progranulin

1

3

High-throughput

0.470

High

278876

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.445

High

1245002

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.445

High

472080

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

516798

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

1245008

KCD12
BTB/POZ domain-containing protein KCTD12

1

12

High-throughput

0.407

High

1245009

PGBD1
PiggyBac transposable element-derived protein 1

1

1

High-throughput

0.407

High

1245013

ENKD1
Enkurin domain-containing protein 1

3

0

High-throughput

0.352

High

1245003

LYPD1
Ly6/PLAUR domain-containing protein 1

3

0

High-throughput

0.345

High

1245011

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1245012

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025