HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.995

The method score is based on:

Property Details
Experiments 25258038, 16275660, 17178836, 25684577, 26232501, 26010904, 27283392, 27709416, 28396517, 29317501, 10330192, 33961781, 16554822, 35148989, 35398354, 15538384, 11557750, 21454478, 20618441, 21911421 and 16 others

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Identification Methods enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, two hybrid, unspecified method, proximity labelling technology, protein complementation assay, nuclear magnetic resonance, filter binding and 2 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANAPC3~HSP70
Common GO terms GO:0001664 - G protein-coupled receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 10 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 646
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024