Protein: H2A2B
Histone H2A type 2-B (H2A-clustered histone 21)

Gene: H2A2B, H2AC21
Organism: Homo sapiens
Interactions: 226
UniProt ID: Q8IUE6

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0030527 - structural constituent of chromatin
GO:0031507 - heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

979935

H4
Histone H4

6

13

High-throughput

0.935

High

1037247

H11
Histone H1.1

4

20

High-throughput

0.900

High

591721

H2AX
Histone H2AX

3

19

High-throughput

0.861

High

936799

NP1L1
Nucleosome assembly protein 1-like 1

3

13

High-throughput

0.861

High

1307292

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.861

High

595501

H15
Histone H1.5

3

20

High-throughput

0.855

High

419065

H2A1B
Histone H2A type 1-B/E

3

19

High-throughput

0.847

High

998507

H31
Histone H3.1

3

20

High-throughput

0.847

High

1307276

SIR6
NAD-dependent protein deacylase sirtuin-6

3

8

High-throughput

0.847

High

1258872

H32
Histone H3.2

3

20

High-throughput

0.827

High

1065284

SSRP1
FACT complex subunit SSRP1

2

19

High-throughput

0.811

High

1307332

H2AW
Core histone macro-H2A.2

2

19

High-throughput

0.811

High

455819

H10
Histone H1.0

2

5

High-throughput

0.802

High

596210

H12
Histone H1.2

2

20

High-throughput

0.802

High

502414

H2A1
Histone H2A type 1

2

19

High-throughput

0.789

High

521790

H14
Histone H1.4

2

20

High-throughput

0.789

High

1163036

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.789

High

1307273

H2B3B
Histone H2B type 3-B

2

20

High-throughput

0.789

High

1067488

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.778

High

754903

H2B1B
Histone H2B type 1-B

2

20

High-throughput

0.754

High

946827

H2B1D
Histone H2B type 1-D

2

20

High-throughput

0.754

High

980902

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

216481

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

4

High-throughput

0.691

High

338888

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.691

High

502045

H2AZ
Histone H2A.Z

1

20

High-throughput

0.691

High

649357

H1T
Histone H1t

1

20

High-throughput

0.691

High

1016999

H33
Histone H3.3

1

20

High-throughput

0.691

High

1232690

H2A2A
Histone H2A type 2-A

1

19

High-throughput

0.691

High

1275353

H2BWT
Histone H2B type W-T

1

20

High-throughput

0.691

High

601756

HMGA1
High mobility group protein HMG-I/HMG-Y

3

6

High-throughput

0.671

High

1307269

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

4

High-throughput

0.667

High

1161925

H31T
Histone H3.1t

1

20

High-throughput

0.665

High

1307288

H1X
Histone H1.10

1

4

High-throughput

0.665

High

1307290

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

1307295

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

8

Small-scale

0.665

High

1307309

MEP50
Methylosome protein WDR77

1

7

Small-scale

0.647

High

969297

RS8
Small ribosomal subunit protein eS8

3

0

High-throughput

0.638

High

187127

PPM1G
Protein phosphatase 1G

2

11

High-throughput

0.635

High

243671

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.618

High

372492

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.618

High

406357

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.618

High

449747

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.618

High

634044

H2A1D
Histone H2A type 1-D

1

19

High-throughput

0.618

High

659914

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.618

High

888174

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

943385

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.618

High

970736

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.618

High

987098

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

17

High-throughput

0.618

High

1106999

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.618

High

1132809

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

1208850

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.618

High

1307289

H2A1C
Histone H2A type 1-C

1

19

High-throughput

0.618

High

1307298

H2A1H
Histone H2A type 1-H

1

19

High-throughput

0.618

High

1307301

H2A1A
Histone H2A type 1-A

1

20

High-throughput

0.618

High

1307302

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.618

High

1307304

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.618

High

1307305

H2A1J
Histone H2A type 1-J

1

19

High-throughput

0.618

High

1307312

H2AJ
Histone H2A.J

1

19

High-throughput

0.618

High

1307336

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.618

High

137460

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

2

10

High-throughput

0.611

High

446534

DPOLB
DNA polymerase beta

2

1

High-throughput

0.611

High

487496

PARP1
Poly [ADP-ribose] polymerase 1

2

20

High-throughput

0.611

High

1307268

APLF
Aprataxin and PNK-like factor

2

4

High-throughput

0.611

High

1307278

ZBT38
Zinc finger and BTB domain-containing protein 38

2

1

High-throughput

0.611

High

1307334

PEF1
Peflin

2

2

High-throughput

0.611

High

422500

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

1307287

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

1197634

MIDN
Midnolin

1

0

High-throughput

0.586

High

1307329

RN146
E3 ubiquitin-protein ligase RNF146

1

0

High-throughput

0.586

High

224901

BUD23
18S rRNA

2

0

High-throughput

0.585

High

1307321

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

2

0

High-throughput

0.585

High

589087

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

1141205

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

1194202

LARP7
La-related protein 7

2

20

High-throughput

0.584

High

1220622

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.553

High

1227006

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.553

High

191697

MAGB2
Melanoma-associated antigen B2

1

6

High-throughput

0.536

High

290618

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.536

High

290950

PPM1B
Protein phosphatase 1B

1

2

High-throughput

0.536

High

428843

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.536

High

481326

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

542106

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

542572

TOP2A
DNA topoisomerase 2-alpha

1

5

High-throughput

0.536

High

586772

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.536

High

615857

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.536

High

686249

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

732639

ARRB2
Beta-arrestin-2

1

4

High-throughput

0.536

High

785278

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

809711

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.536

High

824222

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

882527

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.536

High

898715

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.536

High

961770

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

975793

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

978599

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.536

High

979040

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.536

High

984459

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

984845

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

1006521

SRPK2
SRSF protein kinase 2

1

9

High-throughput

0.536

High

1032832

XPC
DNA repair protein complementing XP-C cells

1

5

High-throughput

0.536

High

1061046

SRSF1
Serine/arginine-rich splicing factor 1

1

11

High-throughput

0.536

High

1062038

SRSF4
Serine/arginine-rich splicing factor 4

1

12

High-throughput

0.536

High

1134635

NUMA1
Nuclear mitotic apparatus protein 1

1

12

High-throughput

0.536

High

1241390

MED27
Mediator of RNA polymerase II transcription subunit 27

1

2

High-throughput

0.536

High

1260367

H1FNT
Testis-specific H1 histone

1

1

High-throughput

0.536

High

1279109

GOGA7
Golgin subfamily A member 7

1

1

High-throughput

0.536

High

1289435

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.536

High

1307277

ZN491
Zinc finger protein 491

1

1

High-throughput

0.536

High

1307280

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.536

High

1307281

FLCN
Folliculin

1

1

High-throughput

0.536

High

1307283

ZN398
Zinc finger protein 398

1

2

High-throughput

0.536

High

1307284

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

2

High-throughput

0.536

High

1307297

ZN668
Zinc finger protein 668

1

2

High-throughput

0.536

High

1307299

ZN512
Zinc finger protein 512

1

2

High-throughput

0.536

High

1307310

MBB1A
Myb-binding protein 1A

1

2

High-throughput

0.536

High

1307313

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

6

High-throughput

0.536

High

1307315

RBM4
RNA-binding protein 4

1

9

High-throughput

0.536

High

1307320

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1307327

PRDM5
PR domain zinc finger protein 5

1

1

High-throughput

0.536

High

1307330

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

1307333

SPAST
Spastin

1

2

High-throughput

0.536

High

1307337

PURG
Purine-rich element-binding protein gamma

1

4

High-throughput

0.536

High

1307338

ZN346
Zinc finger protein 346

1

5

High-throughput

0.536

High

1307339

RUVB2
RuvB-like 2

1

5

High-throughput

0.536

High

1307341

YBOX2
Y-box-binding protein 2

1

19

High-throughput

0.536

High

336451

SVIL
Supervillin

1

1

High-throughput

0.515

High

445950

ENOA
Alpha-enolase

1

1

High-throughput

0.515

High

352485

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

973228

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

985754

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

323938

CMTA2
Calmodulin-binding transcription activator 2

1

0

High-throughput

0.493

High

635202

HNF1A
Hepatocyte nuclear factor 1-alpha

1

0

Small-scale

0.493

High

982989

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.493

High

288692

NPM3
Nucleoplasmin-3

1

8

High-throughput

0.489

High

733391

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.489

High

760465

SDC2
Syndecan-2

1

1

High-throughput

0.489

High

841396

RBM34
RNA-binding protein 34

1

9

High-throughput

0.489

High

842428

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.489

High

860824

RS10
Small ribosomal subunit protein eS10

1

4

High-throughput

0.489

High

909079

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.489

High

986098

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.489

High

1016089

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.489

High

1099147

SRSF5
Serine/arginine-rich splicing factor 5

1

12

High-throughput

0.489

High

1112076

KRR1
KRR1 small subunit processome component homolog

1

4

High-throughput

0.489

High

1124161

LY6D
Lymphocyte antigen 6D

1

1

High-throughput

0.489

High

1127420

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1147631

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.489

High

1152140

MARE1
Microtubule-associated protein RP/EB family member 1

1

2

High-throughput

0.489

High

1254224

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

1290572

ZCH18
Zinc finger CCCH domain-containing protein 18

1

12

High-throughput

0.489

High

1307271

CA174
UPF0688 protein C1orf174

1

2

High-throughput

0.489

High

1307282

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

8

High-throughput

0.489

High

1307286

SSH1
Protein phosphatase Slingshot homolog 1

1

1

High-throughput

0.489

High

1307300

TECTB
Beta-tectorin

1

1

High-throughput

0.489

High

1307311

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.489

High

1307314

ELOV1
Very long chain fatty acid elongase 1

1

1

High-throughput

0.489

High

1307317

MAK16
Protein MAK16 homolog

1

1

High-throughput

0.489

High

1307319

RM18
Large ribosomal subunit protein uL18m

1

1

High-throughput

0.489

High

1307331

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.489

High

1307335

CFDP1
Craniofacial development protein 1

1

4

High-throughput

0.489

High

1307340

KLH20
Kelch-like protein 20

1

1

High-throughput

0.489

High

223164

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

247988

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

260149

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

324972

HEXI1
Protein HEXIM1

1

12

High-throughput

0.479

High

331114

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.479

High

385928

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

Small-scale

0.479

High

424429

HMGN1
Non-histone chromosomal protein HMG-14

1

4

High-throughput

0.479

High

426528

HMGN2
Non-histone chromosomal protein HMG-17

1

10

High-throughput

0.479

High

504920

H2AB2
Histone H2A-Bbd type 2/3

1

20

High-throughput

0.479

High

520602

RARA
Retinoic acid receptor alpha

1

8

Small-scale

0.479

High

567444

TCTP
Translationally-controlled tumor protein

1

3

High-throughput

0.479

High

606897

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

615566

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

629949

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

674232

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

695871

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

755975

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

810200

RL3
Large ribosomal subunit protein uL3

1

3

High-throughput

0.479

High

983875

RBX1
E3 ubiquitin-protein ligase RBX1

1

4

High-throughput

0.479

High

1035754

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

1120235

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

Small-scale

0.479

High

1137382

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1140514

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1271724

MEPCE
7SK snRNA methylphosphate capping enzyme

1

12

High-throughput

0.479

High

1281550

SLN11
Schlafen family member 11

1

6

Small-scale

0.479

High

1307267

ARMC8
Armadillo repeat-containing protein 8

1

2

High-throughput

0.479

High

1307279

SERB1
SERPINE1 mRNA-binding protein 1

1

11

High-throughput

0.479

High

1307294

ZN707
Zinc finger protein 707

1

3

High-throughput

0.479

High

1307296

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

1307316

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

1307322

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

1307323

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1307324

RC3H2
Roquin-2

1

13

High-throughput

0.479

High

1307342

LOXL2
Lysyl oxidase homolog 2

1

4

High-throughput

0.479

High

698320

MAP4
Microtubule-associated protein 4

1

14

High-throughput

0.470

High

1139952

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

High-throughput

0.470

High

1307303

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1307328

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.458

High

47542

RPSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.445

High

96713

E9PAV9
G patch domain-containing protein 4

1

3

High-throughput

0.437

High

157580

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.437

High

272300

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

768586

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

879248

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

1134975

CUL7
Cullin-7

1

1

High-throughput

0.437

High

1215694

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

1233911

Q6ICH2
single-stranded DNA cytosine deaminase

1

5

High-throughput

0.437

High

1307270

TM192
Transmembrane protein 192

1

1

High-throughput

0.437

High

1307285

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

4

High-throughput

0.437

High

1307307

SPI2B
Spindlin-2B

1

1

High-throughput

0.437

High

1307308

RBM4B
RNA-binding protein 4B

1

9

High-throughput

0.437

High

1307318

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

7

High-throughput

0.437

High

1307325

NGB
Neuroglobin

1

1

High-throughput

0.437

High

1307326

ANLN
Anillin

1

3

High-throughput

0.437

High

73419

B2CML4
single-stranded DNA cytosine deaminase

1

5

High-throughput

0.407

High

1212341

GPTC4
G patch domain-containing protein 4

1

3

High-throughput

0.407

High

657261

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

1163586

RTN1
Reticulon-1

1

0

High-throughput

0.279

Low

1307275

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1307291

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

1307293

ZN428
Zinc finger protein 428

1

0

High-throughput

0.279

Low

1307306

F118B
Protein FAM118B

1

0

High-throughput

0.279

Low

1230780

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.269

Low

1307272

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.269

Low

1307274

STX19
Syntaxin-19

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025