HitPredict

Interactor 1: ODB2 (P11182)
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)
Gene: DBT

Interactor 2: ECHM (P30084)
Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH)
Gene: ECHS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0009083 - branched-chain amino acid catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 290
+	Hs
		506004 ODB2_HUMAN (1-482): 0: 635: 100.00		ECHD2_HUMAN (4-290): 7.34e-92: 275: 32.31
+	Hs
		505970 ODB2_HUMAN (1-482): 0: 635: 100.00		ECH1_HUMAN (6-283): 4.3e-83: 254: 24.57
+	Hs
		505973 ODB2_HUMAN (1-482): 0: 635: 100.00		AUHM_HUMAN (1-290): 1.84e-81: 250: 29.67
+	Hs
		739106 ODO2_HUMAN (52-481): 3.5e-140: 412: 24.54		AUHM_HUMAN (1-290): 1.84e-81: 250: 29.67
+	Hs
		489740 ODP2_HUMAN (40-137): 9.92e-23: 103: 21.21		AUHM_HUMAN (1-290): 1.84e-81: 250: 29.67
+	Ec
		420975 ODP2_ECOLI (64-473): 5.99e-45: 168: 29.35		FADJ_ECOLI (45-234): 1.22e-19: 90.5: 29.95