Protein: DLG5
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)

Gene: DLG5
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q8TDM6

Gene Ontology (top 5):
GO:0001837 - epithelial to mesenchymal transition
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

250297

VINEX
Vinexin

3

18

Small-scale

0.874

High

594054

NCK1
SH2/SH3 adapter protein NCK1

2

20

High-throughput

0.776

High

978186

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

966655

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

730080

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.687

High

482936

TPM1
Tropomyosin alpha-1 chain

3

3

High-throughput

0.667

High

991649

DYL1
Dynein light chain 1, cytoplasmic

3

8

High-throughput

0.662

High

1049594

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1351376

DYL2
Dynein light chain 2, cytoplasmic

3

8

High-throughput

0.650

High

691270

1433T
14-3-3 protein theta

3

20

High-throughput

0.643

High

764901

CTNB1
Catenin beta-1

3

8

Small-scale

0.640

High

692100

MARK3
MAP/microtubule affinity-regulating kinase 3

2

2

High-throughput

0.628

High

126713

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

318830

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.618

High

341110

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.618

High

375757

RASK
GTPase KRas

1

20

High-throughput

0.618

High

440154

LCK
Tyrosine-protein kinase Lck

1

13

High-throughput

0.618

High

463667

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

466375

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

601383

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

710385

EPHA2
Ephrin type-A receptor 2

1

17

High-throughput

0.618

High

910142

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

936394

AFAD
Afadin

1

20

High-throughput

0.618

High

953577

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955403

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962303

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962791

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988547

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015625

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1058892

ZO1
Tight junction protein 1

1

18

High-throughput

0.618

High

1145031

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.618

High

1151793

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1254772

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

1270912

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1351367

PARD3
Partitioning defective 3 homolog

1

16

High-throughput

0.618

High

1351369

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1351379

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1351386

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.618

High

1351390

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1351392

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1351399

ZO2
Tight junction protein 2

1

19

High-throughput

0.618

High

459691

PROF1
Profilin-1

2

3

High-throughput

0.614

High

891691

GSK3B
Glycogen synthase kinase-3 beta

2

4

High-throughput

0.584

High

1248161

SAS6
Spindle assembly abnormal protein 6 homolog

2

7

High-throughput

0.584

High

1351405

FBW1A
F-box/WD repeat-containing protein 1A

2

6

Small-scale

0.584

High

1005922

GTF2I
General transcription factor II-I

2

0

High-throughput

0.576

High

222156

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.575

High

1351366

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

19

High-throughput

0.575

High

396575

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

1351381

CEP63
Centrosomal protein of 63 kDa

2

10

High-throughput

0.562

High

948886

CD81
CD81 antigen

1

2

High-throughput

0.541

High

443455

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.536

High

971813

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

990530

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

993257

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.536

High

1113796

CUL3
Cullin-3

1

5

High-throughput

0.536

High

1124664

SRC8
Src substrate cortactin

1

11

High-throughput

0.536

High

1270478

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.536

High

1351380

LURA1
Leucine rich adaptor protein 1

1

3

High-throughput

0.536

High

1351389

SAV1
Protein salvador homolog 1

1

20

High-throughput

0.536

High

1351401

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.536

High

1226193

CP135
Centrosomal protein of 135 kDa

2

3

High-throughput

0.533

High

928498

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

1351385

BTBDA
BTB/POZ domain-containing protein 10

1

0

High-throughput

0.518

High

1351382

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

788113

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.494

High

859648

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.493

High

1135967

MELT
Ventricular zone-expressed PH domain-containing protein homolog 1

1

0

High-throughput

0.493

High

765733

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.489

High

136942

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

9

High-throughput

0.479

High

164398

NRP1
Neuropilin-1

1

6

High-throughput

0.479

High

189732

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

226146

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

245348

CE104
Centrosomal protein of 104 kDa

1

1

High-throughput

0.479

High

247390

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.479

High

299307

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

323499

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.479

High

324186

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.479

High

349175

LATS1
Serine/threonine-protein kinase LATS1

1

11

High-throughput

0.479

High

363603

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

401189

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

412304

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

414274

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

436951

K1C18
Keratin, type I cytoskeletal 18

1

7

High-throughput

0.479

High

437282

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

475643

K1C19
Keratin, type I cytoskeletal 19

1

7

High-throughput

0.479

High

484187

PGFRB
Platelet-derived growth factor receptor beta

1

10

High-throughput

0.479

High

508322

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

537574

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

541606

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

552653

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

556234

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

582891

EZRI
Ezrin

1

20

High-throughput

0.479

High

593451

PGFRA
Platelet-derived growth factor receptor alpha

1

8

High-throughput

0.479

High

604118

CXA1
Gap junction alpha-1 protein

1

17

High-throughput

0.479

High

641219

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.479

High

641631

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.479

High

642985

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

20

High-throughput

0.479

High

648600

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

711918

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

764397

CTNA1
Catenin alpha-1

1

6

High-throughput

0.479

High

767474

RADI
Radixin

1

20

High-throughput

0.479

High

787429

TGFR1
TGF-beta receptor type-1

1

1

Small-scale

0.479

High

845334

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.479

High

872561

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

878523

PAXI
Paxillin

1

10

High-throughput

0.479

High

891257

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.479

High

958157

ARP3
Actin-related protein 3

1

4

High-throughput

0.479

High

986590

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

989058

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

1024716

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1034298

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

1035801

KIF23
Kinesin-like protein KIF23

1

19

High-throughput

0.479

High

1041190

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1045555

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1087208

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1091433

ANK3
Ankyrin-3

1

4

High-throughput

0.479

High

1112617

CUL1
Cullin-1

1

5

Small-scale

0.479

High

1115844

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

1149336

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1152166

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1156159

ZYX
Zyxin

1

8

High-throughput

0.479

High

1159518

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1159768

OCLN
Occludin

1

6

High-throughput

0.479

High

1197032

AMOT
Angiomotin

1

17

High-throughput

0.479

High

1203203

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.479

High

1227122

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

1229004

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

1235304

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.479

High

1252146

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

1273118

MOB1B
MOB kinase activator 1B

1

2

High-throughput

0.479

High

1280298

DNJB7
DnaJ homolog subfamily B member 7

1

2

High-throughput

0.479

High

1280882

CNTRL
Centriolin

1

5

High-throughput

0.479

High

1291553

HOOK3
Protein Hook homolog 3

1

16

High-throughput

0.479

High

1322909

CXD3
Gap junction delta-3 protein

1

17

High-throughput

0.479

High

1351370

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1351375

ENTR1
Endosome-associated-trafficking regulator 1

1

2

High-throughput

0.479

High

1351383

CEP89
Centrosomal protein of 89 kDa

1

10

High-throughput

0.479

High

1351384

LZTS2
Leucine zipper putative tumor suppressor 2

1

18

High-throughput

0.479

High

1351387

GAN
Gigaxonin

1

2

High-throughput

0.479

High

1351388

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

1351391

MOB1A
MOB kinase activator 1A

1

2

High-throughput

0.479

High

1351393

E41LA
Band 4.1-like protein 4A

1

20

High-throughput

0.479

High

1351395

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1351403

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1351404

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

1351407

PHOCN
MOB-like protein phocein

1

2

High-throughput

0.479

High

992274

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1110666

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1143438

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

255135

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

1326004

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1351374

SH3K1
SH3 domain-containing kinase-binding protein 1

1

19

High-throughput

0.445

High

139937

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

164028

NDC80
Kinetochore protein NDC80 homolog

1

7

High-throughput

0.437

High

327373

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

451418

NFM
Neurofilament medium polypeptide

1

10

High-throughput

0.437

High

702018

TMOD1
Tropomodulin-1

1

1

High-throughput

0.437

High

904958

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

1137881

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.437

High

1241914

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

1256530

CE128
Centrosomal protein of 128 kDa

1

13

High-throughput

0.437

High

1293623

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1336796

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

5

High-throughput

0.437

High

1351368

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

7

High-throughput

0.437

High

1351371

GOGA1
Golgin subfamily A member 1

1

2

High-throughput

0.437

High

1351372

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.437

High

1351373

CK052
Uncharacterized protein C11orf52

1

4

High-throughput

0.437

High

1351378

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

9

High-throughput

0.437

High

1351396

ANLN
Anillin

1

4

High-throughput

0.437

High

1351397

SEP10
Septin-10

1

3

High-throughput

0.437

High

1351398

ANFY1
Rabankyrin-5

1

4

High-throughput

0.437

High

1351400

ANC2
Anaphase-promoting complex subunit 2

1

6

High-throughput

0.437

High

1351406

NINL
Ninein-like protein

1

8

High-throughput

0.437

High

686299

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.426

High

326750

DUS14
Dual specificity protein phosphatase 14

1

4

High-throughput

0.407

High

1258516

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

1278545

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

1

High-throughput

0.407

High

1307235

TF2LY
Homeobox protein TGIF2LY

1

1

High-throughput

0.407

High

1351402

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.407

High

341996

CEP43
Centrosomal protein 43

1

0

High-throughput

0.279

Low

122528

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.249

Low

246803

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

298940

DNJB5
DnaJ homolog subfamily B member 5

1

0

High-throughput

0.249

Low

621691

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

1351377

AURKB
Aurora kinase B

1

0

High-throughput

0.249

Low

1351394

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025