HitPredict

Interactor 1: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	36086954, 9566916
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, pull down, anti tag coimmunoprecipitation, phosphatase assay
Interaction Type	physical association, direct interaction, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0032991 - protein-containing complex
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1271 Hs			1 435
+	Hs
		506517 BCR_HUMAN (1-1271): 0: 1005: 100.00		PTN3_HUMAN (3-275): 1.72e-49: 182: 36.43
+	Hs
		506521 BCR_HUMAN (1-1271): 0: 1005: 100.00		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Hs
		573917 ECT2_HUMAN (335-923): 3.96e-71: 259: 17.07		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		573787 RHG12_HUMAN (964-1241): 1.01e-68: 250: 29.64		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		279860 TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72		PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74
+	Hs
		279839 TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72		PTPRD_HUMAN (1-278): 8.51e-109: 354: 31.45
+	Hs
		279833 TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Mm
		420370 VAV_MOUSE (393-1106): 2.14e-78: 279: 11.78		PTPRC_MOUSE (16-343): 7.2e-73: 250: 21.51
+	Mm
		719322 ITSN1_MOUSE (74-927): 4.91e-77: 283: 13.61		PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80
+	Hs
		1078935 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		PTN22_HUMAN (297-430): 8.46e-19: 91.2: 13.10
+	Hs
		548767 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		PTN22_HUMAN (297-430): 8.46e-19: 91.2: 13.10
+	Hs
		1022686 RHG05_HUMAN (900-1263): 2.31e-71: 264: 21.92		PTPRU_HUMAN (341-434): 6.63e-17: 85.4: 13.59
+	Hs
		548649 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48