Protein: CDC25
Cell division control protein 25

Gene: CDC25
Organism: Saccharomyces cerevisiae S288C
Interactions: 97
UniProt ID: P04821

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

376199

RAS2
Ras-like protein 2

9

20

Small-scale

0.975

High

376172

RAS1
Ras-like protein 1

4

20

Small-scale

0.893

High

416839

CDC25
Cell division control protein 25

1

3

Small-scale

0.713

High

416899

MDS3
Negative regulator of sporulation MDS3

4

1

High-throughput

0.700

High

416840

KAPA
cAMP-dependent protein kinase type 1

3

5

Small-scale

0.686

High

416867

HRR25
Casein kinase I homolog HRR25

3

2

Small-scale

0.667

High

391959

HSP82
ATP-dependent molecular chaperone HSP82

3

2

Small-scale

0.648

High

416882

SSZ1
Ribosome-associated complex subunit SSZ1

2

3

High-throughput

0.601

High

416859

PP11
Serine/threonine-protein phosphatase PP1-1

2

0

High-throughput

0.595

High

416912

DIG2
Down-regulator of invasive growth 2

2

0

High-throughput

0.588

High

416875

BRR2
Pre-mRNA-splicing helicase BRR2

2

0

Small-scale

0.587

High

416863

CG23
G2/mitotic-specific cyclin-3

2

0

Small-scale

0.585

High

416854

FUS3
Mitogen-activated protein kinase FUS3

1

3

Small-scale

0.578

High

416888

SA185
SIT4-associating protein SAP185

2

0

High-throughput

0.576

High

416843

CYAA
Adenylate cyclase

1

1

Small-scale

0.561

High

416852

KSS1
Mitogen-activated protein kinase KSS1

1

3

Small-scale

0.561

High

416850

KIN1
Serine/threonine protein kinase KIN1

1

1

High-throughput

0.541

High

416870

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

1

High-throughput

0.541

High

416871

BTAF1
TATA-binding protein-associated factor MOT1

1

1

High-throughput

0.541

High

416874

PMD1
Negative regulator of sporulation PMD1

1

1

High-throughput

0.541

High

416886

VTH1
VPS10 homolog 1

1

1

High-throughput

0.541

High

416887

BNR1
BNI1-related protein 1

1

1

High-throughput

0.541

High

416890

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

High-throughput

0.541

High

416927

EAF3
Chromatin modification-related protein EAF3

1

2

High-throughput

0.541

High

416841

KAPB
cAMP-dependent protein kinase type 2

1

4

High-throughput

0.536

High

416860

MCK1
Protein kinase MCK1

1

3

High-throughput

0.536

High

416868

BMH1
Protein BMH1

1

4

High-throughput

0.536

High

416881

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

3

High-throughput

0.536

High

416848

AK
Aspartokinase

1

0

High-throughput

0.518

High

416851

STE12
Protein STE12

1

0

High-throughput

0.518

High

416861

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.518

High

416864

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.518

High

416869

ACBP
Acyl-CoA-binding protein

1

0

High-throughput

0.518

High

416879

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.518

High

416896

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.518

High

416905

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.518

High

416906

DMA2
E3 ubiquitin-protein ligase DMA2

1

0

High-throughput

0.518

High

416909

ATG21
Autophagy-related protein 21

1

0

High-throughput

0.518

High

416910

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.518

High

416911

MET31
Transcriptional regulator MET31

1

0

High-throughput

0.518

High

416917

RPN7
26S proteasome regulatory subunit RPN7

1

0

High-throughput

0.518

High

416923

PSR2
Probable phosphatase PSR2

1

0

High-throughput

0.518

High

416926

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.518

High

416893

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.517

High

416845

HSP73
Heat shock protein SSA3

1

4

Small-scale

0.515

High

416846

HSP71
Heat shock protein SSA1

1

4

Small-scale

0.515

High

416847

HSP72
Heat shock protein SSA2

1

4

Small-scale

0.515

High

416894

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.513

High

416842

PBS2
MAP kinase kinase PBS2

1

4

High-throughput

0.501

High

416849

INO1
Inositol-3-phosphate synthase

1

1

High-throughput

0.501

High

416865

NFS1
Cysteine desulfurase, mitochondrial

1

1

High-throughput

0.501

High

416872

IME2
Meiosis induction protein kinase IME2/SME1

1

2

High-throughput

0.501

High

416889

KEG1
Beta-1,6-glucan synthesis-associated protein KEG1

1

1

High-throughput

0.501

High

416898

ALG10
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

1

High-throughput

0.501

High

416900

LSG1
Large subunit GTPase 1

1

1

High-throughput

0.501

High

416919

BSP1
F-actin capping regulator BSP1

1

1

High-throughput

0.501

High

416929

YI31B
Transposon Ty3-I Gag-Pol polyprotein

1

1

High-throughput

0.501

High

416857

IRA1
Inhibitory regulator protein IRA1

1

2

High-throughput

0.494

High

416903

RT19
Small ribosomal subunit protein uS19m

1

1

High-throughput

0.494

High

416172

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.480

High

416855

SPO7
Sporulation-specific protein SPO7

1

0

High-throughput

0.480

High

416862

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.480

High

416876

PRX1
Peroxiredoxin PRX1, mitochondrial

1

0

High-throughput

0.480

High

416877

IMB2
Importin subunit beta-2

1

0

Small-scale

0.480

High

416883

LCF3
Long-chain-fatty-acid--CoA ligase 3

1

0

High-throughput

0.480

High

416901

FHN1
Non-classical export protein 2 homolog 1

1

0

High-throughput

0.480

High

416914

SSY1
SPS-sensor component SSY1

1

0

High-throughput

0.480

High

416915

TPP1
Polynucleotide 3'-phosphatase

1

0

High-throughput

0.480

High

416921

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

High-throughput

0.480

High

416858

CG12
G1/S-specific cyclin CLN2

1

1

Small-scale

0.479

High

416853

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

416866

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

416873

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.458

High

416891

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

416895

ASK10
Activator of SKN7 protein 10

1

0

High-throughput

0.458

High

416908

MUK1
Protein MUK1

1

0

High-throughput

0.458

High

416916

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

416918

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

416922

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

416925

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

416892

YJ00
UPF0508 protein YJR030C

1

1

High-throughput

0.457

High

416897

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.457

High

416904

YN93
Uncharacterized hydrolase YNR064C

1

1

High-throughput

0.457

High

416920

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.445

High

416844

PRTB
Cerevisin

1

2

High-throughput

0.437

High

416884

NPR2
Nitrogen permease regulator 2

1

1

High-throughput

0.437

High

416885

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

416913

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.426

High

416880

YB75
Uncharacterized protein YBR225W

4

0

High-throughput

0.356

High

416878

YBQ3
Uncharacterized protein YBR053C

1

0

High-throughput

0.282

High

416907

SPR6
Sporulation-specific protein

1

0

High-throughput

0.282

High

416856

COQ1
Hexaprenyl pyrophosphate synthase, mitochondrial

1

0

High-throughput

0.261

Low

416902

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.261

Low

60147

YM084
Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.251

Low

416928

IRC11
Putative increased recombination centers protein 11

1

0

High-throughput

0.238

Low

416924

CWC2
Pre-mRNA-splicing factor CWC2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025