HitPredict

Interactor 1: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	8621719, 20675402, 14725908, 19380743
Identification Methods	pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1271 Hs			1 906
+	Hs
		610415 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		548639 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610397 ARHG7_HUMAN (369-1044): 2.29e-75: 269: 13.98		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610656 ITSN1_MOUSE (74-927): 4.91e-77: 283: 13.61		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		1027606 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		548699 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		1027604 ARHG7_HUMAN (369-1044): 2.29e-75: 269: 13.98		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		69201 A9UF07_HUMAN (690-1072): 3.04e-27: 122: 60.83		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610465 HMHA1_HUMAN (1041-1221): 3.88e-21: 102: 36.28		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		69208 A9UF07_HUMAN (690-1072): 3.04e-27: 122: 60.83		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		203228 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		1186092 ECT2_HUMAN (335-923): 3.96e-71: 259: 17.07		MICA3_HUMAN (406-905): 3.1e-14: 79.6: 11.67
+	Hs
		1056991 ECT2_HUMAN (335-923): 3.96e-71: 259: 17.07		MDC1_HUMAN (450-878): 1.89e-11: 70.3: 9.33
+	Hs
		1071122 RBP1_HUMAN (1051-1211): 4.99e-20: 98.2: 34.55		CRBG2_HUMAN (456-876): 1.43e-12: 74.1: 16.49
+	Hs
		1268317 HMHA1_HUMAN (1041-1221): 3.88e-21: 102: 36.28		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		1071144 RBP1_HUMAN (1051-1211): 4.99e-20: 98.2: 34.55		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25