HitPredict

Interactor 1: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2~SH2, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1271 Hs			1 261
+	Hs
		442768 BCR_HUMAN (1-1271): 0: 1005: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		506538 BCR_HUMAN (1-1271): 0: 1005: 100.00		FRK_HUMAN (27-260): 2.98e-71: 228: 24.50
+	Hs
		337325 BCR_HUMAN (1-1271): 0: 1005: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		275167 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		506565 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Mm
		1141138 BCR_MOUSE (1-1271): 0: 941: 93.79		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		337453 ABR_HUMAN (419-1271): 0: 567: 66.47		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		433726 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		433781 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		411981 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		411673 FGD1_HUMAN (162-971): 1.22e-77: 279: 13.57		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		411580 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		548690 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		BTK_HUMAN (10-260): 1.44e-64: 214: 21.46
+	Hs
		548654 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		TEC_HUMAN (7-260): 1.36e-62: 208: 21.81
+	Hs
		337333 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		924658 FGD6_HUMAN (93-969): 1.47e-86: 311: 14.15		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		924525 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Mm
		654982 VAV_MOUSE (393-1106): 2.14e-78: 279: 11.78		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		548677 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		924777 Q96D37_HUMAN (393-1092): 1.17e-77: 275: 12.29		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39