HitPredict

Interactor 1: PIM1 (P11309)
Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)
Gene: PIM1

Interactor 2: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.933

The method score is based on:

Property Details
Experiments 15319445, 26186194, 28514442, 33961781, 32707033
Identification Methods pull down, affinity chromatography technology, two hybrid, enzymatic study, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains KA1~Pkinase, Pkinase~Pkinase, Pkinase~UBA
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 2 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 313
Hs

1 753
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+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024