Protein: MAP4
Microtubule-associated protein 4 (MAP-4)

Gene: MAP4
Organism: Homo sapiens
Interactions: 246
UniProt ID: P27816

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0003723 - RNA binding
GO:0005198 - structural molecule activity
GO:0005815 - microtubule organizing center
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

529141

TAU
Microtubule-associated protein tau

4

16

High-throughput

0.892

High

698236

YAP1
Transcriptional coactivator YAP1

3

20

Small-scale

0.640

High

395536

ESR1
Estrogen receptor

3

20

High-throughput

0.633

High

457046

CAN1
Calpain-1 catalytic subunit

2

8

High-throughput

0.621

High

698221

MAP4
Microtubule-associated protein 4

1

15

High-throughput

0.618

High

279119

ULK1
Serine/threonine-protein kinase ULK1

2

20

Small-scale

0.611

High

534676

BIP
Endoplasmic reticulum chaperone BiP

2

19

High-throughput

0.611

High

698348

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

10

High-throughput

0.601

High

371228

MYC
Myc proto-oncogene protein

2

13

High-throughput

0.584

High

698334

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

4

Small-scale

0.584

High

698352

RANB9
Ran-binding protein 9

2

15

Small-scale

0.584

High

698375

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

1

Small-scale

0.584

High

631072

RAB5A
Ras-related protein Rab-5A

2

18

High-throughput

0.571

High

698341

OTUB1
Ubiquitin thioesterase OTUB1

2

2

High-throughput

0.571

High

698338

FBXW7
F-box/WD repeat-containing protein 7

1

11

Small-scale

0.561

High

698307

RICTR
Rapamycin-insensitive companion of mTOR

2

0

High-throughput

0.559

High

698247

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.552

High

698343

NEUL4
Neuralized-like protein 4

2

1

High-throughput

0.549

High

376479

LDLR
Low-density lipoprotein receptor

1

2

High-throughput

0.541

High

479114

ENOG
Gamma-enolase

1

8

High-throughput

0.541

High

122712

KIF2A
Kinesin-like protein KIF2A

1

9

High-throughput

0.536

High

213072

CP110
Centriolar coiled-coil protein of 110 kDa

1

2

High-throughput

0.536

High

214545

WDR62
WD repeat-containing protein 62

1

10

High-throughput

0.536

High

287870

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

7

High-throughput

0.536

High

334275

TACC2
Transforming acidic coiled-coil-containing protein 2

1

14

High-throughput

0.536

High

342756

HERC2
E3 ubiquitin-protein ligase HERC2

1

14

High-throughput

0.536

High

389061

FINC
Fibronectin

1

9

High-throughput

0.536

High

412932

CPNS1
Calpain small subunit 1

1

10

High-throughput

0.536

High

462256

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

13

High-throughput

0.536

High

698235

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.536

High

698243

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.536

High

698246

BLM
RecQ-like DNA helicase BLM

1

14

High-throughput

0.536

High

698254

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.536

High

698264

RAE1L
mRNA export factor RAE1

1

15

High-throughput

0.536

High

698265

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

High-throughput

0.536

High

698269

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.536

High

698271

ILF3
Interleukin enhancer-binding factor 3

1

16

High-throughput

0.536

High

698282

EPN4
Clathrin interactor 1

1

10

High-throughput

0.536

High

698284

KIF22
Kinesin-like protein KIF22

1

11

High-throughput

0.536

High

698293

MK06
Mitogen-activated protein kinase 6

1

14

High-throughput

0.536

High

698295

MA7D1
MAP7 domain-containing protein 1

1

19

High-throughput

0.536

High

698297

PDZ11
PDZ domain-containing protein 11

1

14

High-throughput

0.536

High

698322

CKP2L
Cytoskeleton-associated protein 2-like

1

1

High-throughput

0.536

High

698329

MIPT3
TRAF3-interacting protein 1

1

6

Small-scale

0.536

High

698332

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.536

High

698349

SPAG5
Sperm-associated antigen 5

1

20

High-throughput

0.536

High

698355

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

698356

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

3

High-throughput

0.536

High

698357

KIF2C
Kinesin-like protein KIF2C

1

14

High-throughput

0.536

High

698362

TBCD
Tubulin-specific chaperone D

1

1

High-throughput

0.536

High

698371

PKHA5
Pleckstrin homology domain-containing family A member 5

1

19

High-throughput

0.536

High

698379

SLTM
SAFB-like transcription modulator

1

18

High-throughput

0.536

High

698386

RALY
RNA-binding protein Raly

1

6

High-throughput

0.536

High

698390

CP131
Centrosomal protein of 131 kDa

1

10

High-throughput

0.536

High

698399

EPN1
Epsin-1

1

11

High-throughput

0.536

High

105389

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

259482

BRD4
Bromodomain-containing protein 4

2

13

High-throughput

0.533

High

587973

RFA2
Replication protein A 32 kDa subunit

2

7

High-throughput

0.533

High

694683

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

7

High-throughput

0.533

High

698229

RFA3
Replication protein A 14 kDa subunit

2

5

High-throughput

0.533

High

698277

SNTA1
Alpha-1-syntrophin

1

11

Small-scale

0.527

High

698351

ERBIN
Erbin

1

2

Small-scale

0.527

High

595322

H15
Histone H1.5

1

13

High-throughput

0.515

High

642640

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.515

High

698232

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

698294

MIC60
MICOS complex subunit MIC60

1

5

High-throughput

0.515

High

698396

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.515

High

698369

FA83D
Protein FAM83D

1

0

High-throughput

0.513

High

698240

GSK3B
Glycogen synthase kinase-3 beta

1

16

High-throughput

0.508

High

698378

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.504

High

443198

CDK1
Cyclin-dependent kinase 1

1

10

Small-scale

0.501

High

507558

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

High-throughput

0.501

High

698255

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

698263

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.501

High

698346

MARK4
MAP/microtubule affinity-regulating kinase 4

1

11

Small-scale

0.501

High

166622

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

2

High-throughput

0.489

High

246218

MABP1
Mitogen-activated protein kinase-binding protein 1

1

13

High-throughput

0.489

High

698266

CBX1
Chromobox protein homolog 1

1

7

High-throughput

0.489

High

698279

CUL4A
Cullin-4A

1

15

High-throughput

0.489

High

698324

SPRY3
SPRY domain-containing protein 3

1

15

High-throughput

0.489

High

698325

SLAI1
SLAIN motif-containing protein 1

1

1

High-throughput

0.489

High

698326

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

698361

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

18

High-throughput

0.489

High

698395

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.489

High

698223

RXRB
Retinoic acid receptor RXR-beta

1

20

High-throughput

0.481

High

698251

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.481

High

698285

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

High-throughput

0.481

High

698314

CLAP1
CLIP-associating protein 1

1

7

High-throughput

0.481

High

698353

STRBP
Spermatid perinuclear RNA-binding protein

1

16

High-throughput

0.481

High

698393

NOP58
Nucleolar protein 58

1

1

High-throughput

0.481

High

131749

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

12

High-throughput

0.479

High

164798

UN13B
Protein unc-13 homolog B

1

13

High-throughput

0.479

High

179148

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

17

Small-scale

0.479

High

217859

TGON2
Trans-Golgi network integral membrane protein 2

1

17

High-throughput

0.479

High

221236

DCX
Neuronal migration protein doublecortin

1

5

Small-scale

0.479

High

229305

ZBT14
Zinc finger and BTB domain-containing protein 14

1

2

High-throughput

0.479

High

247234

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.479

High

256779

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

302385

RNF8
E3 ubiquitin-protein ligase RNF8

1

7

High-throughput

0.479

High

323188

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

345402

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

17

High-throughput

0.479

High

347539

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.479

High

362814

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

375200

RASK
GTPase KRas

1

20

High-throughput

0.479

High

400319

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

411404

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

413241

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

425329

ISG15
Ubiquitin-like protein ISG15

1

15

High-throughput

0.479

High

536553

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

555887

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

557881

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

583196

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

593918

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

618985

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

8

High-throughput

0.479

High

698222

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.479

High

698224

PML
Protein PML

1

16

High-throughput

0.479

High

698225

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

698226

GRK5
G protein-coupled receptor kinase 5

1

19

High-throughput

0.479

High

698228

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

698230

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

698231

BRCA1
Breast cancer type 1 susceptibility protein

1

14

High-throughput

0.479

High

698233

EPS15
Epidermal growth factor receptor substrate 15

1

6

High-throughput

0.479

High

698242

HDGF
Hepatoma-derived growth factor

1

9

High-throughput

0.479

High

698244

KIF11
Kinesin-like protein KIF11

1

13

High-throughput

0.479

High

698245

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

698248

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

7

High-throughput

0.479

High

698250

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

698252

UBC12
NEDD8-conjugating enzyme Ubc12

1

6

High-throughput

0.479

High

698253

ABCE1
ATP-binding cassette sub-family E member 1

1

3

High-throughput

0.479

High

698256

WDR5
WD repeat-containing protein 5

1

19

High-throughput

0.479

High

698257

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

16

High-throughput

0.479

High

698258

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

698259

RS14
Small ribosomal subunit protein uS11

1

4

Small-scale

0.479

High

698260

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

698262

TBA1B
Tubulin alpha-1B chain

1

16

High-throughput

0.479

High

698267

SET
Protein SET

1

3

High-throughput

0.479

High

698268

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

698270

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

698272

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

9

High-throughput

0.479

High

698273

TADBP
TAR DNA-binding protein 43

1

19

High-throughput

0.479

High

698274

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

698276

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.479

High

698278

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

698280

DCTN1
Dynactin subunit 1

1

18

High-throughput

0.479

High

698283

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

Small-scale

0.479

High

698287

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

698288

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

698289

PCBP1
Poly(rC)-binding protein 1

1

13

Small-scale

0.479

High

698291

EZH2
Histone-lysine N-methyltransferase EZH2

1

13

High-throughput

0.479

High

698296

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

698298

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.479

High

698299

CE170
Centrosomal protein of 170 kDa

1

20

High-throughput

0.479

High

698300

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

698302

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

698303

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

698304

ANO7
Anoctamin-7

1

1

Small-scale

0.479

High

698306

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

698309

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

698315

PABP2
Polyadenylate-binding protein 2

1

15

High-throughput

0.479

High

698317

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

698318

ZCH18
Zinc finger CCCH domain-containing protein 18

1

19

High-throughput

0.479

High

698321

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

698327

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

698328

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

698333

TOPB1
DNA topoisomerase 2-binding protein 1

1

14

High-throughput

0.479

High

698335

HDAC2
Histone deacetylase 2

1

14

High-throughput

0.479

High

698339

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.479

High

698340

AP2M1
AP-2 complex subunit mu

1

10

High-throughput

0.479

High

698347

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

698358

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

20

High-throughput

0.479

High

698359

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

698360

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.479

High

698363

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.479

High

698364

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.479

High

698370

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

698372

NGB
Neuroglobin

1

1

High-throughput

0.479

High

698373

BRD7
Bromodomain-containing protein 7

1

18

High-throughput

0.479

High

698374

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

698376

ANLN
Anillin

1

6

High-throughput

0.479

High

698382

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

698383

HDAC6
Protein deacetylase HDAC6

1

15

High-throughput

0.479

High

698384

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

698385

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

12

Small-scale

0.479

High

698387

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.479

High

698389

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

698392

MARE3
Microtubule-associated protein RP/EB family member 3

1

10

High-throughput

0.479

High

698320

H2A2B
Histone H2A type 2-B

1

14

High-throughput

0.470

High

657490

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

698249

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

698281

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.458

High

698367

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

107290

F8VRK0
Tubulin alpha 1b

1

13

High-throughput

0.445

High

354552

PAK4
Serine/threonine-protein kinase PAK 4

1

7

High-throughput

0.445

High

404684

PRIO
Major prion protein

1

3

High-throughput

0.445

High

429348

JUN
Transcription factor Jun

1

8

High-throughput

0.445

High

619522

VCAM1
Vascular cell adhesion protein 1

1

13

High-throughput

0.445

High

698227

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.445

High

698261

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.445

High

698305

NCLX
Mitochondrial sodium/calcium exchanger protein

1

5

High-throughput

0.445

High

698316

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

20

High-throughput

0.445

High

698319

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

698330

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.445

High

698336

B2CL2
Bcl-2-like protein 2

1

2

High-throughput

0.445

High

698342

S41A3
Solute carrier family 41 member 3

1

1

High-throughput

0.445

High

698365

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

698368

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

13

High-throughput

0.445

High

698237

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.439

High

194005

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

324564

HEXI1
Protein HEXIM1

1

1

High-throughput

0.437

High

554162

BMP4
Bone morphogenetic protein 4

1

3

High-throughput

0.437

High

606270

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.437

High

612881

EGR1
Early growth response protein 1

1

4

High-throughput

0.437

High

698238

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.437

High

698241

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.437

High

698275

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.437

High

698286

EMC2
ER membrane protein complex subunit 2

1

10

High-throughput

0.437

High

698292

E2F4
Transcription factor E2F4

1

6

High-throughput

0.437

High

698301

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

698308

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

698310

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

698311

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.437

High

698313

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.437

High

698337

FGF11
Fibroblast growth factor 11

1

3

High-throughput

0.437

High

698354

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

698366

RNF38
E3 ubiquitin-protein ligase RNF38

1

2

Small-scale

0.437

High

698377

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.437

High

698380

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

698381

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

698388

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.437

High

698391

TRI33
E3 ubiquitin-protein ligase TRIM33

1

18

High-throughput

0.437

High

698394

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

698397

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.437

High

698398

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.437

High

133442

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.426

High

698290

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

698344

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

698323

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

698345

C170L
Cep170-like protein

1

5

High-throughput

0.407

High

698239

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.373

High

698234

RAD52
DNA repair protein RAD52 homolog

1

0

High-throughput

0.279

Low

698312

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.279

Low

698350

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.279

Low

590812

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

698331

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.249

Low

62454

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025