HitPredict

Interactor 1: KRAF1 (P11346)
Raf homolog serine/threonine-protein kinase Raf (D-Raf) (dRAF-1) (EC 2.7.11.1) (Protein pole-hole)
Gene: Raf

Interactor 2: Q24171 (Q24171)
AT08303p (KSR) (Kinase suppressor of ras) (Kinase suppressor of ras, isoform B) (Kinase suppressor of ras, isoform C) (Kinase suppressor of ras, isoform D)
Gene: ksr

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.767

The method score is based on:

Property Details
Experiments 22028469, 19727074
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~C1_1, C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, C1_1~RBD
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0007265 - Ras protein signal transduction
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 739
Dm

1 966
+ Dm
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Last updated: 15 Jul 2024