HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.727

Property	Details
Experiments	35384245, 22974441
Identification Methods	proximity labelling technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010976 - positive regulation of neuron projection development and 1 others more... GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 377
+	Hs
		208983 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		507897 FGFR1_HUMAN (1-822): 0: 861: 100.00		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		507870 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129184 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		508045 FGFR1_HUMAN (1-822): 0: 861: 100.00		SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84
+	Hs
		508022 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		507818 FGFR1_HUMAN (1-822): 0: 861: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		507939 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		508233 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05
+	Hs
		433229 FGFR1_HUMAN (1-822): 0: 861: 100.00		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		508140 FGFR1_HUMAN (1-822): 0: 861: 100.00		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		601463 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129199 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		412008 FGFR2_HUMAN (1-821): 0: 803: 71.21		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		522773 FGFR2_HUMAN (1-821): 0: 803: 71.21		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 803: 71.21		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		601605 FGFR2_HUMAN (1-821): 0: 803: 71.21		ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05
+	Hs
		609182 FGFR3_HUMAN (6-821): 0: 730: 61.22		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		609244 FGFR3_HUMAN (6-821): 0: 730: 61.22		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		129201 FGFR4_HUMAN (29-808): 0: 664: 55.60		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61