HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.980

The method score is based on:

Property Details
Experiments 19665973, 20932831, 15117958, 8321198, 18022941, 9660748, 35384245, 36736316, 23063561, 1656221
Identification Methods affinity chromatography technology, pull down, two hybrid, enzymatic study, x-ray crystallography, fluorescent resonance energy transfer, proximity labelling technology, protein kinase assay, isothermal titration calorimetry, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0001701 - in utero embryonic development
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0016477 - cell migration
GO:0043536 - positive regulation of blood vessel endothelial cell migration
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

1 1290
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Last updated: 15 Jul 2024