HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: IL3RA (P26951)
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
Gene: IL3RA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	IL6Ra-bind~ig
Common GO terms	GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 378
+	Hs
		601461 FGFR2_HUMAN (1-821): 0: 803: 71.21		IL3RA_HUMAN (18-378): 7.15e-106: 317: 100.00
+	Hs
		508207 FGFR1_HUMAN (1-822): 0: 861: 100.00		CRLF2_HUMAN (100-362): 9.4e-38: 141: 12.77
+	Hs
		601594 FGFR2_HUMAN (1-821): 0: 803: 71.21		CRLF2_HUMAN (100-362): 9.4e-38: 141: 12.77
+	Hs
		609255 FGFR3_HUMAN (6-821): 0: 730: 61.22		IL5RA_HUMAN (1-375): 9.47e-63: 208: 25.18
+	Hs
		607943 FGFR4_HUMAN (29-808): 0: 664: 55.60		IL5RA_HUMAN (1-375): 9.47e-63: 208: 25.18
+	Hs
		609549 FGFR3_HUMAN (6-821): 0: 730: 61.22		CRLF2_HUMAN (100-362): 9.4e-38: 141: 12.77
+	Hs
		265756 FGFR4_HUMAN (29-808): 0: 664: 55.60		CRLF1_HUMAN (1-301): 9.6e-44: 158: 14.02
+	Hs
		607974 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA7_HUMAN (66-284): 7.33e-40: 152: 13.50
+	Hs
		608141 FGFR4_HUMAN (29-808): 0: 664: 55.60		CRLF2_HUMAN (100-362): 9.4e-38: 141: 12.77
+	Hs
		665676 EPHB2_HUMAN (4-819): 0: 640: 18.07		EPHA6_HUMAN (66-333): 5.04e-42: 159: 12.37
+	Hs
		665399 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHA7_HUMAN (66-284): 7.33e-40: 152: 13.50
+	Hs
		665605 EPHB2_HUMAN (4-819): 0: 640: 18.07		EPHA7_HUMAN (66-284): 7.33e-40: 152: 13.50
+	Hs
		665567 EPHB2_HUMAN (4-819): 0: 640: 18.07		EPHB1_HUMAN (42-327): 2.1e-38: 148: 13.10
+	Hs
		265771 EPHA7_HUMAN (3-783): 0: 629: 19.40		CRLF1_HUMAN (1-301): 9.6e-44: 158: 14.02
+	Hs
		665374 EPHB2_HUMAN (4-819): 0: 640: 18.07		EPHA3_HUMAN (60-329): 8.89e-36: 140: 11.00
+	Hs
		665383 EPHA5_HUMAN (3-791): 0: 639: 19.15		EPHA3_HUMAN (60-329): 8.89e-36: 140: 11.00
+	Hs
		665477 EPHA7_HUMAN (3-783): 0: 629: 19.40		EPHA8_HUMAN (67-330): 2.75e-37: 145: 12.46
+	Hs
		665385 EPHA4_HUMAN (3-783): 0: 620: 19.44		EPHA3_HUMAN (60-329): 8.89e-36: 140: 11.00
+	Hs
		562563 EPHA7_HUMAN (3-783): 0: 629: 19.40		IL7RA_HUMAN (181-348): 2.43e-28: 117: 15.26