Protein: DHB4
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]

Gene: DHB4, HSD17B4
Organism: Homo sapiens
Interactions: 159
UniProt ID: P51659

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0001649 - osteoblast differentiation
GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881132

FAS
Fatty acid synthase

1

2

High-throughput

0.691

High

647428

SCP2
Sterol carrier protein 2

1

4

High-throughput

0.665

High

906402

IKZF1
DNA-binding protein Ikaros

3

1

High-throughput

0.662

High

906383

DHB4
Peroxisomal multifunctional enzyme type 2

1

18

Small-scale

0.647

High

896223

PEX5
Peroxisomal targeting signal 1 receptor

3

6

Small-scale

0.631

High

897169

CDK7
Cyclin-dependent kinase 7

2

1

High-throughput

0.614

High

278833

PEX14
Peroxisomal membrane protein PEX14

2

1

Small-scale

0.588

High

399953

CATA
Catalase

2

3

High-throughput

0.588

High

906426

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.588

High

122479

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

2

2

High-throughput

0.584

High

241141

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

345547

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

891386

GSK3B
Glycogen synthase kinase-3 beta

2

1

High-throughput

0.584

High

906413

ITSN1
Intersectin-1

2

0

High-throughput

0.547

High

906398

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.541

High

370605

FOS
Protein c-Fos

1

1

High-throughput

0.536

High

563451

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

711853

LTK
Leukocyte tyrosine kinase receptor

1

5

High-throughput

0.536

High

906400

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.536

High

906422

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

1

High-throughput

0.536

High

906449

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

2

High-throughput

0.536

High

853630

MK08
Mitogen-activated protein kinase 8

1

0

High-throughput

0.518

High

906438

NDRG1
Protein NDRG1

1

1

Small-scale

0.515

High

165763

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.513

High

776942

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

787946

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

906391

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

906406

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.513

High

906446

SORT
Sortilin

1

0

High-throughput

0.513

High

906450

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

551774

CO6A1

1

0

High-throughput

0.493

High

470935

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.489

High

484442

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

471459

PLEK
Pleckstrin

1

2

Small-scale

0.484

High

61461

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

332089

MRP6
ATP-binding cassette sub-family C member 6

1

1

Small-scale

0.479

High

403924

GCR
Glucocorticoid receptor

1

8

Small-scale

0.479

High

410723

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.479

High

411610

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

413444

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

458339

ADRB2
Beta-2 adrenergic receptor

1

3

High-throughput

0.479

High

507699

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

609969

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.479

High

623203

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

High-throughput

0.479

High

637866

NF1
Neurofibromin

1

1

High-throughput

0.479

High

731107

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

767138

MERL
Merlin

1

2

High-throughput

0.479

High

772113

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

862757

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.479

High

906388

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

906390

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.479

High

906392

RELB
Transcription factor RelB

1

1

High-throughput

0.479

High

906395

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

906401

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

906404

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

906405

CUL4B
Cullin-4B

1

1

High-throughput

0.479

High

906411

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

906421

CDC73
Parafibromin

1

1

High-throughput

0.479

High

906424

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

2

High-throughput

0.479

High

906430

LMTK2
Serine/threonine-protein kinase LMTK2

1

4

High-throughput

0.479

High

906442

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

4

Small-scale

0.479

High

906443

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

1

High-throughput

0.479

High

906455

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

906456

RC3H2
Roquin-2

1

1

Small-scale

0.479

High

906459

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

2

Small-scale

0.479

High

906461

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.479

High

906464

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

906465

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

906469

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

906429

TRI59
Tripartite motif-containing protein 59

1

6

High-throughput

0.470

High

906384

CASP9
Caspase-9

1

0

High-throughput

0.460

High

906414

BAK
Bcl-2 homologous antagonist/killer

1

0

High-throughput

0.460

High

128874

MEN1
Menin

1

0

High-throughput

0.458

High

315305

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

373847

RASN
GTPase NRas

1

0

High-throughput

0.458

High

408751

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

488210

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

0

Small-scale

0.458

High

536787

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

904481

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

906385

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

906386

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.458

High

906389

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

906397

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

906409

CUL7
Cullin-7

1

0

High-throughput

0.458

High

906410

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

906412

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

906418

MIDN
Midnolin

1

0

High-throughput

0.458

High

906423

SUSD1
Sushi domain-containing protein 1

1

0

High-throughput

0.458

High

906427

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

906431

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.458

High

906433

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

906434

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

906435

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

906440

SGK3
Serine/threonine-protein kinase Sgk3

1

0

Small-scale

0.458

High

906444

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

906447

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

906452

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

906454

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

906457

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

906458

ANLN
Anillin

1

0

High-throughput

0.458

High

906460

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

906466

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

906467

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.458

High

327871

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

906420

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

906451

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

142903

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.437

High

227437

SPOP
Speckle-type POZ protein

1

4

Small-scale

0.437

High

318670

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.437

High

330773

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.437

High

473866

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.437

High

588248

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

648467

FGFR4
Fibroblast growth factor receptor 4

1

5

High-throughput

0.437

High

650094

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

694973

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767742

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

786989

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

851468

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.437

High

906387

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

906393

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

5

High-throughput

0.437

High

906396

MERTK
Tyrosine-protein kinase Mer

1

3

High-throughput

0.437

High

906399

DUS4
Dual specificity protein phosphatase 4

1

3

High-throughput

0.437

High

906408

NFIX
Nuclear factor 1 X-type

1

2

High-throughput

0.437

High

906415

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

Small-scale

0.437

High

906419

RC3H1
Roquin-1

1

1

Small-scale

0.437

High

906425

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

906439

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

906453

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

906463

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

354605

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

529379

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

838026

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

906416

TYSD1
Peroxisomal leader peptide-processing protease

1

0

Small-scale

0.426

High

906448

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

371513

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.407

High

906394

TAGL
Transgelin

1

2

High-throughput

0.407

High

906403

S39A6
Zinc transporter ZIP6

1

2

High-throughput

0.407

High

791194

SYUA
Alpha-synuclein

1

0

Small-scale

0.391

High

886654

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

724011

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

238874

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.269

Low

50062

ANO9
Anoctamin-9

1

0

High-throughput

0.249

Low

105604

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

194064

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

297519

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.249

Low

878807

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

906407

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

906432

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

906436

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

906437

PHF10
PHD finger protein 10

1

0

High-throughput

0.249

Low

906441

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

906445

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

906462

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

906468

MTL5
Tesmin

1

0

High-throughput

0.249

Low

344137

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

429556

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

906417

SV2C
Synaptic vesicle glycoprotein 2C

1

0

High-throughput

0.232

Low

906428

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025